Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis

The deubiquitinase USP5 stabilizes c-Maf, a key transcription factor in multiple myeloma (MM), but the mechanisms and significance are unclear. In the present study, USP5 was found to interact with c-Maf and prevented it from degradation by decreasing its polyubiquitination level. Specifically, the...

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Veröffentlicht in:	Cell death & disease 2017-09, Vol.8 (9), p.e3058-e3058
Hauptverfasser:	Wang, Siyu, Juan, Jiaxiang, Zhang, Zubin, Du, Yanyun, Xu, Yujia, Tong, Jiefei, Cao, Biyin, Moran, Michael F, Zeng, Yuanying, Mao, Xinliang
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/109 13/2 631/45/474 631/67/1990/804 631/80/458/582 631/80/82/23 82 82/83 Antibodies Apoptosis Apoptosis - genetics Biochemistry c-Maf protein Cell Biology Cell Culture Cell proliferation Cell survival Endopeptidases - chemistry Endopeptidases - metabolism Enzymes Gene Knockdown Techniques HEK293 Cells Humans Immunology Life Sciences Lysine Lysine - metabolism Maf protein Molecular Targeted Therapy Multiple myeloma Multiple Myeloma - genetics Multiple Myeloma - metabolism Multiple Myeloma - pathology Original original-article Polyubiquitin - metabolism Protein Binding Protein Domains Protein expression Protein Stability Proteolysis Proto-Oncogene Proteins c-maf - metabolism Structure-Activity Relationship Substrate specificity Survival Transcription, Genetic Ubiquitination
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