Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1

Sirtuins (Sirt1–Sirt7) are NAD⁺-dependent protein deacetylases/ADP ribosyltransferases, which play decisive roles in chromatin silencing, cell cycle regulation, cellular differentiation, and metabolism. Different sirtuins control similar cellular processes, suggesting a coordinated mode of action bu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-10, Vol.114 (40), p.E8352-E8361
Hauptverfasser:	Fang, Jian, Ianni, Alessandro, Smolka, Christian, Vakhrusheva, Olesya, Nolte, Hendrik, Krüger, Marcus, Wietelmann, Astrid, Simonet, Nicolas G., Adrian-Segarra, Juan M., Vaquero, Alejandro, Braun, Thomas, Bober, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Adipocytes Adipogenesis Adipose tissue Biological Sciences Catalysis Cell cycle Cells Chromatin Crosstalk Differentiation (biology) Metabolism Mice Mode of action NAD p53 Protein PNAS Plus Rodents Signaling SIRT1 protein Sirtuins
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