Systems Study on the Antirheumatic Mechanism of Tibetan Medicated-Bath Therapy Using Wuwei-Ganlu-Yaoyu-Keli
In clinical practice at Tibetan area of China, Traditional Tibetan Medicine formula Wuwei-Ganlu-Yaoyu-Keli (WGYK) is commonly added in warm water of bath therapy to treat rheumatoid arthritis (RA). However, its mechanism of action is not well interpreted yet. In this paper, we first verify WGYK’s an...
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| Veröffentlicht in: | BioMed research international 2017-01, Vol.2017 (2017), p.1-10 |
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| creator | Ga, Yang Zhang, Yi Wang, Jing Zhao, Kehui Chen, Xing Yang, Jian Wang, Tianhong Zhao, Jing |
| description | In clinical practice at Tibetan area of China, Traditional Tibetan Medicine formula Wuwei-Ganlu-Yaoyu-Keli (WGYK) is commonly added in warm water of bath therapy to treat rheumatoid arthritis (RA). However, its mechanism of action is not well interpreted yet. In this paper, we first verify WGYK’s anti-RA effect by an animal experiment. Then, based on gene expression data from microarray experiments, we apply approaches of network pharmacology to further reveal the mechanism of action for WGYK to treat RA by analyzing protein-protein interactions and pathways. This study may facilitate our understanding of anti-RA effect of WGYK from perspective of network pharmacology. |
| doi_str_mv | 10.1155/2017/2320932 |
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However, its mechanism of action is not well interpreted yet. In this paper, we first verify WGYK’s anti-RA effect by an animal experiment. Then, based on gene expression data from microarray experiments, we apply approaches of network pharmacology to further reveal the mechanism of action for WGYK to treat RA by analyzing protein-protein interactions and pathways. This study may facilitate our understanding of anti-RA effect of WGYK from perspective of network pharmacology.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2017/2320932</identifier><identifier>PMID: 29090217</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acids ; Animal research ; Arthritis ; Bioinformatics ; Biology ; Care and treatment ; Chinese medicine ; DNA microarrays ; Drug dosages ; Experiments ; Folk medicine ; Gene expression ; Genomes ; Immunology ; Inflammation ; Medicine, Primitive ; Metabolism ; Ontology ; Patient outcomes ; Pharmacology ; Protein interaction ; Rheumatoid arthritis ; Rodents ; Therapy ; Warm water</subject><ispartof>BioMed research international, 2017-01, Vol.2017 (2017), p.1-10</ispartof><rights>Copyright © 2017 Tianhong Wang et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Tianhong Wang et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Tianhong Wang et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-7693f1242d53eb9509c6330eef6be61c4df2c5f88322c0eb369e74ee8948de623</citedby><cites>FETCH-LOGICAL-c499t-7693f1242d53eb9509c6330eef6be61c4df2c5f88322c0eb369e74ee8948de623</cites><orcidid>0000-0002-2439-2876 ; 0000-0002-6053-8641</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635470/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635470/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29090217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ning, Kang</contributor><creatorcontrib>Ga, Yang</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Zhao, Kehui</creatorcontrib><creatorcontrib>Chen, Xing</creatorcontrib><creatorcontrib>Yang, Jian</creatorcontrib><creatorcontrib>Wang, Tianhong</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><title>Systems Study on the Antirheumatic Mechanism of Tibetan Medicated-Bath Therapy Using Wuwei-Ganlu-Yaoyu-Keli</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>In clinical practice at Tibetan area of China, Traditional Tibetan Medicine formula Wuwei-Ganlu-Yaoyu-Keli (WGYK) is commonly added in warm water of bath therapy to treat rheumatoid arthritis (RA). However, its mechanism of action is not well interpreted yet. In this paper, we first verify WGYK’s anti-RA effect by an animal experiment. Then, based on gene expression data from microarray experiments, we apply approaches of network pharmacology to further reveal the mechanism of action for WGYK to treat RA by analyzing protein-protein interactions and pathways. This study may facilitate our understanding of anti-RA effect of WGYK from perspective of network pharmacology.</description><subject>Acids</subject><subject>Animal research</subject><subject>Arthritis</subject><subject>Bioinformatics</subject><subject>Biology</subject><subject>Care and treatment</subject><subject>Chinese medicine</subject><subject>DNA microarrays</subject><subject>Drug dosages</subject><subject>Experiments</subject><subject>Folk medicine</subject><subject>Gene expression</subject><subject>Genomes</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Medicine, Primitive</subject><subject>Metabolism</subject><subject>Ontology</subject><subject>Patient outcomes</subject><subject>Pharmacology</subject><subject>Protein interaction</subject><subject>Rheumatoid arthritis</subject><subject>Rodents</subject><subject>Therapy</subject><subject>Warm 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Study on the Antirheumatic Mechanism of Tibetan Medicated-Bath Therapy Using Wuwei-Ganlu-Yaoyu-Keli</title><author>Ga, Yang ; Zhang, Yi ; Wang, Jing ; Zhao, Kehui ; Chen, Xing ; Yang, Jian ; Wang, Tianhong ; Zhao, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-7693f1242d53eb9509c6330eef6be61c4df2c5f88322c0eb369e74ee8948de623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acids</topic><topic>Animal research</topic><topic>Arthritis</topic><topic>Bioinformatics</topic><topic>Biology</topic><topic>Care and treatment</topic><topic>Chinese medicine</topic><topic>DNA microarrays</topic><topic>Drug dosages</topic><topic>Experiments</topic><topic>Folk medicine</topic><topic>Gene expression</topic><topic>Genomes</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Medicine, Primitive</topic><topic>Metabolism</topic><topic>Ontology</topic><topic>Patient 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(WGYK) is commonly added in warm water of bath therapy to treat rheumatoid arthritis (RA). However, its mechanism of action is not well interpreted yet. In this paper, we first verify WGYK’s anti-RA effect by an animal experiment. Then, based on gene expression data from microarray experiments, we apply approaches of network pharmacology to further reveal the mechanism of action for WGYK to treat RA by analyzing protein-protein interactions and pathways. This study may facilitate our understanding of anti-RA effect of WGYK from perspective of network pharmacology.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29090217</pmid><doi>10.1155/2017/2320932</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2439-2876</orcidid><orcidid>https://orcid.org/0000-0002-6053-8641</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Animal research Arthritis Bioinformatics Biology Care and treatment Chinese medicine DNA microarrays Drug dosages Experiments Folk medicine Gene expression Genomes Immunology Inflammation Medicine, Primitive Metabolism Ontology Patient outcomes Pharmacology Protein interaction Rheumatoid arthritis Rodents Therapy Warm water |
| title | Systems Study on the Antirheumatic Mechanism of Tibetan Medicated-Bath Therapy Using Wuwei-Ganlu-Yaoyu-Keli |
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