Effects of Brucine on the OPG/RANKL/RANK Signaling Pathway in MDA-MB-231 and MC3T3-E1 Cell Coculture System

The present study examined the effects of brucine on the OPG/RANKL/RANK signaling pathway for exploring the mechanism of brucine suppression of bone metastasis in breast cancer. MDA-MB-231 breast cancer cells and mouse osteoblast MC3T3-E1 cells were cocultured to mimic the breast cancer bone metasta...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-6
Hauptverfasser:	Hu, Kefei, Pei, Xiaohua, Li, Qian, Wu, Ruixian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alkaloids Bone cancer Bone resorption Breast cancer Cell culture Chemical properties Comparative analysis Complications and side effects Cytokines Gene expression Health aspects Metabolism Metastases Metastasis Nux vomica Osteoblastogenesis Osteoclastogenesis Osteoclasts Osteoclasts (Biology) Osteoprotegerin Physiological aspects Physiology Prevention Ribonucleic acid Risk factors RNA Secretion Signal transduction TRANCE protein Tumor necrosis factor-TNF Western blotting
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