Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart

The post-natal heart adapts to stress and overload through hypertrophic growth, a process that may be pathologic or beneficial （physiologic hypertrophy）. Physiologic hypertrophy improves cardiac performance in both healthy and diseased individuals, yet the mechanisms that propagate this f~vorable ad...

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Veröffentlicht in:	Cell research 2017-10, Vol.27 (10), p.1195-1215
Hauptverfasser:	Abdul-Ghani, Mohammad, Suen, Colin, Jiang, Baohua, Deng, Yupu, Weldrick, Jonathan J, Putinski, Charis, Brunette, Steve, Fernando, Pasan, Lee, Tom T, Flynn, Peter, Leenen, Frans H H, Burgon, Patrick G, Stewart, Duncan J, Megeney, Lynn A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/127 692/4019/592/75/74 692/700/565/1331 Angiogenesis Animals Biomedical and Life Sciences Cardiomyocytes Caspase Cell Biology Coronary artery disease Cytokines - administration & dosage Cytokines - genetics Delivery contracts Eutrophication Heart Heart - growth & development Heart - physiopathology Heart diseases Heart Failure - genetics Heart Failure - physiopathology Humans Hypertrophy Life Sciences Mice Muscle contraction Muscle Development - genetics Myocardium Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Original original-article Rats Signal Transduction Vascular Remodeling - genetics 心肌肥大心脏功能生理性生长特征病理性营养素血管重塑
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