Wenshen Zhuanggu formula effectively suppresses breast cancer bone metastases in a mouse xenograft model

Wenshen ZhuanggLi formula （WSZG） is a traditional Chinese medicine used as an adjuvant for the prevention of bone metastases in breast cancer patients. In this study we investigated the efficacy of WSZG in preventing bone metastases and the potential mechanisms in a mouse xenograft model of breast c...

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Veröffentlicht in:	Acta pharmacologica Sinica 2017-10, Vol.38 (10), p.1369-1380
Hauptverfasser:	Li, Jia-jia, Chen, Wei-ling, Wang, Jian-yi, Hu, Qian-wen, Sun, Zhen-ping, Zhang, Shuai, Liu, Sheng, Han, Xiang-hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Biomedical and Life Sciences Biomedicine Bone cancer Bone imaging Bone lesions Bone marrow Bone Neoplasms - prevention & control Bone Neoplasms - secondary Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology CCR5 protein Chinese medicine Computed tomography Diphosphonates - pharmacology Dose-Response Relationship, Drug Female Glycoproteins Heart Humans Imidazoles - pharmacology Immunoglobulins Immunology Injection Internal Medicine Lesions Medical Microbiology Mentoring programs Mesenchymal Stromal Cells - cytology Mesenchyme Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Original original-article Osteoclasts - metabolism Pharmacology/Toxicology Plant Extracts - administration & dosage Plant Extracts - pharmacology Stem cell transplantation Stem cells Traditional Chinese medicine Tumor Microenvironment Vaccine Ventricle Xenograft Model Antitumor Assays Xenografts Zoledronic acid 乳腺癌细胞公式小鼠异种移植模型肿瘤干细胞阳性对照骨髓间充质干细胞
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