A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction
Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated and . IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)...
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| Veröffentlicht in: | Oncotarget 2017-09, Vol.8 (39), p.65717-65729 |
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| creator | Li, Juan Zhang, Chun-Xia Liu, Yi-Mei Chen, Ke-Li Chen, Gang |
| description | Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated
and
. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage. Moreover, they could up-regulate telomerase (TE) activity, increase expressions of SIRT1, forkhead box 3a (Foxo3a), active regulator of SIRT1 (AROS) and Hu antigen R (HuR ), but decrease p53 and deleted in breast cancer 1 (DBC1) levels. However, 10 μM resveratrol
and the high dose group
showed relatively stronger activities of anti-aging and stimulating SIRT1 level than CR. In conclusion, resveratrol and CR showed similar anti-aging activities on SIRT1 signaling, implicating the potential of resveratrol as a CR mimetic. |
| doi_str_mv | 10.18632/oncotarget.20084 |
| format | Article |
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and
. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage. Moreover, they could up-regulate telomerase (TE) activity, increase expressions of SIRT1, forkhead box 3a (Foxo3a), active regulator of SIRT1 (AROS) and Hu antigen R (HuR ), but decrease p53 and deleted in breast cancer 1 (DBC1) levels. However, 10 μM resveratrol
and the high dose group
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and
. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage. Moreover, they could up-regulate telomerase (TE) activity, increase expressions of SIRT1, forkhead box 3a (Foxo3a), active regulator of SIRT1 (AROS) and Hu antigen R (HuR ), but decrease p53 and deleted in breast cancer 1 (DBC1) levels. However, 10 μM resveratrol
and the high dose group
showed relatively stronger activities of anti-aging and stimulating SIRT1 level than CR. In conclusion, resveratrol and CR showed similar anti-aging activities on SIRT1 signaling, implicating the potential of resveratrol as a CR mimetic.</description><subject>Research Paper</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVUU1LxDAQDaKorPsDvEiPXrrmq2niQRDxCxa86DlM07RG2qYm2QX_vXV3_ZrLDG_mvZnhIXRK8IJIweiFH4xPEFqbFhRjyffQMVFc5bQo2P6f-gjNY3zDUxS8lFQdoiOqMFVciGOkrzPj-xECJLe2WUyr-iPzTQZDcjm0bmizMfjRhuRsnNA66615hcHF_jILNq7txAy-27QMdD4484WnKSfnhxN00EAX7XyXZ-jl7vb55iFfPt0_3lwvc8MpTTkRJfBalrjishGVMbKuGFMSS8qVUZUopRBNySoiQGFWAIG6oQRKyzFIrNgMXW11x1XV29rYIQXo9BhcD-FDe3D6f2dwr7r1a10IhpkQk8D5TiD499X0gO5dNLbrYLB-FTVRBeGkwIRPo2Q7aoKPMdjmZw3BeuON_vVGb7yZOGd_7_thfDvBPgGYBo98</recordid><startdate>20170912</startdate><enddate>20170912</enddate><creator>Li, Juan</creator><creator>Zhang, Chun-Xia</creator><creator>Liu, Yi-Mei</creator><creator>Chen, Ke-Li</creator><creator>Chen, Gang</creator><general>Impact Journals LLC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170912</creationdate><title>A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction</title><author>Li, Juan ; Zhang, Chun-Xia ; Liu, Yi-Mei ; Chen, Ke-Li ; Chen, Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-167a4d870b48f6bcc8db339808249c9b67866f73b16a9035a1adf21a7e40a8093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Research Paper</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Zhang, Chun-Xia</creatorcontrib><creatorcontrib>Liu, Yi-Mei</creatorcontrib><creatorcontrib>Chen, Ke-Li</creatorcontrib><creatorcontrib>Chen, Gang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Juan</au><au>Zhang, Chun-Xia</au><au>Liu, Yi-Mei</au><au>Chen, Ke-Li</au><au>Chen, Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-09-12</date><risdate>2017</risdate><volume>8</volume><issue>39</issue><spage>65717</spage><epage>65729</epage><pages>65717-65729</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated
and
. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage. Moreover, they could up-regulate telomerase (TE) activity, increase expressions of SIRT1, forkhead box 3a (Foxo3a), active regulator of SIRT1 (AROS) and Hu antigen R (HuR ), but decrease p53 and deleted in breast cancer 1 (DBC1) levels. However, 10 μM resveratrol
and the high dose group
showed relatively stronger activities of anti-aging and stimulating SIRT1 level than CR. In conclusion, resveratrol and CR showed similar anti-aging activities on SIRT1 signaling, implicating the potential of resveratrol as a CR mimetic.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>29029466</pmid><doi>10.18632/oncotarget.20084</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | NCBI_PubMed Central（免费）; Open Access: Freely Accessible Journals by multiple vendors; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Research Paper |
| title | A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction |
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