Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells

mTORC1 hyperactivation drives the multi-organ hamartomatous disease tuberous sclerosis complex (TSC). Rapamycin inhibits mTORC1, inducing partial tumor responses; however, the tumors regrow following treatment cessation. We discovered that the oncogenic miRNA, miR-21, is increased in Tsc2-deficient...

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Veröffentlicht in:	Oncotarget 2017-09, Vol.8 (39), p.64714-64727
Hauptverfasser:	Lam, Hilaire C, Liu, Heng-Jia, Baglini, Christian V, Filippakis, Harilaos, Alesi, Nicola, Nijmeh, Julie, Du, Heng, Lope, Alicia Llorente, Cottrill, Katherine A, Handen, Adam, Asara, John M, Kwiatkowski, David J, Ben-Sahra, Issam, Oldham, William M, Chan, Stephen Y, Henske, Elizabeth P
Format:	Artikel
Sprache:	eng
Schlagworte:	Priority Research Paper
Online-Zugang:	Volltext
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