RNA-binding proteins in neurodegeneration: mechanisms in aggregate

Neurodegeneration is a leading cause of death in the developed world and a natural, albeit unfortunate, consequence of longer-lived populations. Despite great demand for therapeutic intervention, it is often the case that these diseases are insufficiently understood at the basic molecular level. Wha...

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Veröffentlicht in:	Genes & development 2017-08, Vol.31 (15), p.1509-1528
Hauptverfasser:	Conlon, Erin G, Manley, James L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Microsatellite Repeats - genetics Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurons - metabolism Organelles - metabolism Review RNA - metabolism RNA Processing, Post-Transcriptional RNA-Binding Protein FUS - genetics RNA-Binding Protein FUS - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism
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