Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013
ObjectiveTo evaluate mortality risks of angiosarcoma of the liver (ASL), primary hepatocellular carcinoma (HCC) and other cancers among 9951 men employed between 1942 and 1972 at 35 US vinyl chloride (VC) or polyvinyl chloride plants followed for mortality through 31 December 2013.MethodsSMR and tim...
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| Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 2017-10, Vol.74 (10), p.709-716 |
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| creator | Mundt, Kenneth A Dell, Linda D Crawford, Lori Gallagher, Alexa E |
| description | ObjectiveTo evaluate mortality risks of angiosarcoma of the liver (ASL), primary hepatocellular carcinoma (HCC) and other cancers among 9951 men employed between 1942 and 1972 at 35 US vinyl chloride (VC) or polyvinyl chloride plants followed for mortality through 31 December 2013.MethodsSMR and time-dependent Cox proportional hazards analyses were used to evaluate mortality risks by cumulative VC exposure.ResultsLiver cancer mortality was elevated (SMR=2.87, 95% CI 2.40 to 3.40), and ASL and HCC were strongly associated with cumulative VC exposure ≥865 parts per million-years (ppm-years) (ASL: HR=36.3, 95% CI 13.1 to 100.5; and HCC: HR=5.3, 95% CI 1.6 to 17.7 for ≥2271 ppm-years). Excess deaths due to connective and soft tissue cancers (SMR=2.43, 95% CI 1.48 to 3.75), mesothelioma (SMR=2.29, 95% CI 1.18 to 4.00) and explosions (SMR=3.43, 95% CI 1.25 to 7.47) were seen. Mortalities due to melanoma, brain cancer, lung cancer and non-Hodgkin’s lymphoma were not increased or associated with VC exposure.ConclusionThe association between VC and ASL first reported in this cohort 44 years ago persisted and was strongest among workers most highly exposed. VC exposure also was associated with HCC mortality, although it remains possible that misdiagnosis of early ASLs influenced findings. |
| doi_str_mv | 10.1136/oemed-2016-104051 |
| format | Article |
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Excess deaths due to connective and soft tissue cancers (SMR=2.43, 95% CI 1.48 to 3.75), mesothelioma (SMR=2.29, 95% CI 1.18 to 4.00) and explosions (SMR=3.43, 95% CI 1.25 to 7.47) were seen. Mortalities due to melanoma, brain cancer, lung cancer and non-Hodgkin’s lymphoma were not increased or associated with VC exposure.ConclusionThe association between VC and ASL first reported in this cohort 44 years ago persisted and was strongest among workers most highly exposed. VC exposure also was associated with HCC mortality, although it remains possible that misdiagnosis of early ASLs influenced findings.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oemed-2016-104051</identifier><identifier>PMID: 28490663</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Brain ; Brain cancer ; Cancer ; Cause of Death ; Explosions ; Exposure ; Factories ; Hazards ; Health risk assessment ; Health risks ; Hemangiosarcoma - mortality ; Hepatocellular carcinoma ; Hodgkin's lymphoma ; Humans ; Liver ; Liver - drug effects ; Liver cancer ; Liver Neoplasms - mortality ; Lung cancer ; Lymphoma ; Male ; Manufacturing Industry ; Melanoma ; Mesothelioma ; Middle Aged ; Mortality ; Mortality risk ; Non-Hodgkin's lymphoma ; Occupational Diseases - mortality ; Occupational exposure ; Occupational Exposure - adverse effects ; Polyvinyl chloride ; Polyvinyl Chloride - adverse effects ; Proportional Hazards Models ; Risk ; United States - epidemiology ; Vinyl chloride ; Vinyl Chloride - adverse effects ; Workplace</subject><ispartof>Occupational and environmental medicine (London, England), 2017-10, Vol.74 (10), p.709-716</ispartof><rights>Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.</rights><rights>Article author(s) 2017</rights><rights>Copyright: 2017 © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.</rights><rights>Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b486t-fe1c77e8cce6d69e9b2ef27171d4c9093bba5b87bb9e7ef597f13481099ed6083</citedby><cites>FETCH-LOGICAL-b486t-fe1c77e8cce6d69e9b2ef27171d4c9093bba5b87bb9e7ef597f13481099ed6083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26578251$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26578251$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28490663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mundt, Kenneth A</creatorcontrib><creatorcontrib>Dell, Linda D</creatorcontrib><creatorcontrib>Crawford, Lori</creatorcontrib><creatorcontrib>Gallagher, Alexa E</creatorcontrib><title>Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>ObjectiveTo evaluate mortality risks of angiosarcoma of the liver (ASL), primary hepatocellular carcinoma (HCC) and other cancers among 9951 men employed between 1942 and 1972 at 35 US vinyl chloride (VC) or polyvinyl chloride plants followed for mortality through 31 December 2013.MethodsSMR and time-dependent Cox proportional hazards analyses were used to evaluate mortality risks by cumulative VC exposure.ResultsLiver cancer mortality was elevated (SMR=2.87, 95% CI 2.40 to 3.40), and ASL and HCC were strongly associated with cumulative VC exposure ≥865 parts per million-years (ppm-years) (ASL: HR=36.3, 95% CI 13.1 to 100.5; and HCC: HR=5.3, 95% CI 1.6 to 17.7 for ≥2271 ppm-years). Excess deaths due to connective and soft tissue cancers (SMR=2.43, 95% CI 1.48 to 3.75), mesothelioma (SMR=2.29, 95% CI 1.18 to 4.00) and explosions (SMR=3.43, 95% CI 1.25 to 7.47) were seen. Mortalities due to melanoma, brain cancer, lung cancer and non-Hodgkin’s lymphoma were not increased or associated with VC exposure.ConclusionThe association between VC and ASL first reported in this cohort 44 years ago persisted and was strongest among workers most highly exposed. VC exposure also was associated with HCC mortality, although it remains possible that misdiagnosis of early ASLs influenced findings.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Cancer</subject><subject>Cause of Death</subject><subject>Explosions</subject><subject>Exposure</subject><subject>Factories</subject><subject>Hazards</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Hemangiosarcoma - mortality</subject><subject>Hepatocellular carcinoma</subject><subject>Hodgkin's lymphoma</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - mortality</subject><subject>Lung cancer</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Manufacturing Industry</subject><subject>Melanoma</subject><subject>Mesothelioma</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mortality risk</subject><subject>Non-Hodgkin's lymphoma</subject><subject>Occupational Diseases - mortality</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Polyvinyl chloride</subject><subject>Polyvinyl Chloride - adverse effects</subject><subject>Proportional Hazards Models</subject><subject>Risk</subject><subject>United States - epidemiology</subject><subject>Vinyl chloride</subject><subject>Vinyl Chloride - adverse 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estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013</title><author>Mundt, Kenneth A ; Dell, Linda D ; Crawford, Lori ; Gallagher, Alexa E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b486t-fe1c77e8cce6d69e9b2ef27171d4c9093bba5b87bb9e7ef597f13481099ed6083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain</topic><topic>Brain cancer</topic><topic>Cancer</topic><topic>Cause of Death</topic><topic>Explosions</topic><topic>Exposure</topic><topic>Factories</topic><topic>Hazards</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Hemangiosarcoma - mortality</topic><topic>Hepatocellular carcinoma</topic><topic>Hodgkin's lymphoma</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - mortality</topic><topic>Lung cancer</topic><topic>Lymphoma</topic><topic>Male</topic><topic>Manufacturing Industry</topic><topic>Melanoma</topic><topic>Mesothelioma</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Mortality risk</topic><topic>Non-Hodgkin's lymphoma</topic><topic>Occupational Diseases - mortality</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - adverse effects</topic><topic>Polyvinyl chloride</topic><topic>Polyvinyl Chloride - adverse effects</topic><topic>Proportional Hazards Models</topic><topic>Risk</topic><topic>United States - epidemiology</topic><topic>Vinyl chloride</topic><topic>Vinyl Chloride - adverse effects</topic><topic>Workplace</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mundt, Kenneth A</creatorcontrib><creatorcontrib>Dell, Linda D</creatorcontrib><creatorcontrib>Crawford, Lori</creatorcontrib><creatorcontrib>Gallagher, Alexa E</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni 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Collection</collection><collection>Environmental Science Collection</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Occupational and environmental medicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mundt, Kenneth A</au><au>Dell, Linda D</au><au>Crawford, Lori</au><au>Gallagher, Alexa E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013</atitle><jtitle>Occupational and environmental medicine (London, England)</jtitle><addtitle>Occup Environ Med</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>74</volume><issue>10</issue><spage>709</spage><epage>716</epage><pages>709-716</pages><issn>1351-0711</issn><eissn>1470-7926</eissn><abstract>ObjectiveTo evaluate mortality risks of angiosarcoma of the liver (ASL), primary hepatocellular carcinoma (HCC) and other cancers among 9951 men employed between 1942 and 1972 at 35 US vinyl chloride (VC) or polyvinyl chloride plants followed for mortality through 31 December 2013.MethodsSMR and time-dependent Cox proportional hazards analyses were used to evaluate mortality risks by cumulative VC exposure.ResultsLiver cancer mortality was elevated (SMR=2.87, 95% CI 2.40 to 3.40), and ASL and HCC were strongly associated with cumulative VC exposure ≥865 parts per million-years (ppm-years) (ASL: HR=36.3, 95% CI 13.1 to 100.5; and HCC: HR=5.3, 95% CI 1.6 to 17.7 for ≥2271 ppm-years). Excess deaths due to connective and soft tissue cancers (SMR=2.43, 95% CI 1.48 to 3.75), mesothelioma (SMR=2.29, 95% CI 1.18 to 4.00) and explosions (SMR=3.43, 95% CI 1.25 to 7.47) were seen. Mortalities due to melanoma, brain cancer, lung cancer and non-Hodgkin’s lymphoma were not increased or associated with VC exposure.ConclusionThe association between VC and ASL first reported in this cohort 44 years ago persisted and was strongest among workers most highly exposed. VC exposure also was associated with HCC mortality, although it remains possible that misdiagnosis of early ASLs influenced findings.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>28490663</pmid><doi>10.1136/oemed-2016-104051</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adult Aged Aged, 80 and over Brain Brain cancer Cancer Cause of Death Explosions Exposure Factories Hazards Health risk assessment Health risks Hemangiosarcoma - mortality Hepatocellular carcinoma Hodgkin's lymphoma Humans Liver Liver - drug effects Liver cancer Liver Neoplasms - mortality Lung cancer Lymphoma Male Manufacturing Industry Melanoma Mesothelioma Middle Aged Mortality Mortality risk Non-Hodgkin's lymphoma Occupational Diseases - mortality Occupational exposure Occupational Exposure - adverse effects Polyvinyl chloride Polyvinyl Chloride - adverse effects Proportional Hazards Models Risk United States - epidemiology Vinyl chloride Vinyl Chloride - adverse effects Workplace |
| title | Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013 |
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