System modeling reveals the molecular mechanisms of HSC cell cycle alteration mediated by Maff and Egr3 under leukemia

Molecular mechanisms of the functional alteration of hematopoietic stem cells (HSCs) in leukemic environment attract intensive research interests. As known in previous researches, Maff and Egr3 are two important genes having opposite functions on cell cycle; however, they are both highly expressed i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BMC systems biology 2017-10, Vol.11 (Suppl 5), p.91-91, Article 91
Hauptverfasser:	Li, Rudong, Wang, Yin, Cheng, Hui, Liu, Gang, Cheng, Tao, Liu, Yunlong, Liu, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer Cell cycle Computer applications Consolidation Cyclin-dependent kinases Data mining Development and progression Early Growth Response Protein 3 - metabolism Egr-3 protein Experiments Gene expression Gene Expression Regulation, Neoplastic Genes Genetic aspects Growth Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Humans Kinases Leukemia Leukemia - genetics Leukemia - metabolism Leukemia - pathology MafF Transcription Factor - metabolism Models, Biological Molecular modelling Signal transduction Stem cells Studies Systems Biology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!