O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies

The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression a...

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Veröffentlicht in:	Leukemia 2017-10, Vol.31 (10), p.2132-2142
Hauptverfasser:	Freund, P, Kerenyi, M A, Hager, M, Wagner, T, Wingelhofer, B, Pham, H T T, Elabd, M, Han, X, Valent, P, Gouilleux, F, Sexl, V, Krämer, O H, Groner, B, Moriggl, R
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/31 13/95 45/77 45/90 631/250/580 631/337/458/1733 631/337/572 631/67/1990 631/67/2327 631/80/86 64/60 692/308/575 82 82/29 96/1 Acetylglucosamine - metabolism AKT protein Animals Biochemistry, Molecular Biology Cancer Cancer Research Care and treatment Cell Line Cell proliferation Cell Transformation, Neoplastic Cellular Biology Critical Care Medicine Development and progression Differentiation Female Gene expression Gene Expression Regulation, Neoplastic Genes, Reporter Genetic aspects Genetic transformation Glycosylation Health aspects Hematology Humans Intensive Interleukin-3 - pharmacology Internal Medicine Kinases Leukemia Life Sciences Lymphoid Tissue - cytology Male Medicine Medicine & Public Health Metabolism Mice Mutagenesis, Site-Directed Myeloproliferative Disorders - etiology Myeloproliferative Disorders - genetics O-GlcNAcylation Oligomerization Oncology Original original-article Phosphorylation Phosphotyrosine - metabolism Post-translation Protein Processing, Post-Translational Radiation Chimera Recombinant Fusion Proteins - metabolism Signal Transduction STAT5 Stat5 protein STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - metabolism Threonine - metabolism Transcription Transcription (Genetics) Transcriptional Activation Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tyrosine
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