Preclinical targeting of aggressive T-cell malignancies using anti-CD5 chimeric antigen receptor

The outlook for T-cell malignancies remain poor due to the lack of effective therapeutic options. Chimeric antigen receptor (CAR) immunotherapy has recently shown promise in clinical trials for B-cell malignancies, however, designing CARs for T-cell based disease remain a challenge due to the shared...

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Veröffentlicht in:	Leukemia 2017-10, Vol.31 (10), p.2151-2160
Hauptverfasser:	Chen, K H, Wada, M, Pinz, K G, Liu, H, Lin, K-W, Jares, A, Firor, A E, Shuai, X, Salman, H, Golightly, M, Lan, F, Senzel, L, Leung, E L, Jiang, X, Ma, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 4-1BB Ligand - genetics 4-1BB Ligand - immunology 631/250/1904 631/250/232 631/67/1990 64/60 692/4028/67/1059/2325 692/699/67/1990/283/2125 692/699/67/1990/291/1621/1916 692/700/1750 Acute lymphoblastic leukemia Animal models Animals Anticancer properties Antigens Antigens, Neoplasm - immunology Antitumor agents Blood diseases Cancer Research Care and treatment CD28 Antigens - immunology CD3 Complex - genetics CD3 Complex - immunology CD5 antigen CD5 Antigens - immunology CD8 Antigens - immunology Cell Line, Tumor Cell receptors Chimeric antigen receptors Clinical trials Coculture Techniques Critical Care Medicine Cytotoxicity Cytotoxicity, Immunologic Development and progression Disease control Genetic aspects Health aspects Hematology Humans Immunotherapy Immunotherapy, Adoptive - methods Innovations Intensive Internal Medicine Killer Cells, Natural - immunology Killer Cells, Natural - transplantation Leukemia Lymphatic leukemia Lymphocytes B Lymphocytes T Lymphoma Lymphoma, T-Cell, Peripheral - pathology Lymphoma, T-Cell, Peripheral - therapy Medical research Medicine Medicine & Public Health Mice Molecular Targeted Therapy Natural killer cells Oncology Original original-article Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy Recombinant Fusion Proteins - immunology Salvage Therapy Single-Chain Antibodies - genetics Single-Chain Antibodies - immunology T cell receptors T cells Toxicity Transduction, Genetic Tumor cell lines Tumor cells Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology Xenograft Model Antitumor Assays Xenografts
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