Endometrial receptivity in the eutopic endometrium of women with endometriosis—it is affected: let me show you why
The endometrium maintains complex controls on proliferation and apoptosis as part of repetitive menstrual cycles that prepare the endometrium for the window of implantation and pregnancy. The reliance on inflammatory mechanisms for both implantation and menstruation creates the opportunity in the se...
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| Veröffentlicht in: | Fertility and sterility 2017-07, Vol.108 (1), p.19-27 |
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| container_title | Fertility and sterility |
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| creator | Lessey, Bruce A., M.D., Ph.D Kim, J. Julie, Ph.D |
| description | The endometrium maintains complex controls on proliferation and apoptosis as part of repetitive menstrual cycles that prepare the endometrium for the window of implantation and pregnancy. The reliance on inflammatory mechanisms for both implantation and menstruation creates the opportunity in the setting of endometriosis for establishment of chronic inflammation that is disruptive to endometrial receptivity, causing both infertility and abnormal bleeding. Clinically, there can be little doubt that the endometrium of women with endometriosis is less receptive to embryo implantation, and strong evidence exists to suggest that endometrial changes are associated with decreased cycle fecundity as a result of this disease. Here we provide unifying concepts regarding those changes and how they are coordinated to promote progesterone resistance and estrogen dominance through aberrant cell signaling pathways and reduced expression of key homeostatic proteins in eutopic endometrium of women with endometriosis. |
| doi_str_mv | 10.1016/j.fertnstert.2017.05.031 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Embryo Implantation - immunology Embryo Transfer - methods endometrial receptivity Endometriosis Endometriosis - immunology endometrium Endometrium - immunology Endometrium - pathology Evidence-Based Medicine Female Fertilization in Vitro - methods Humans implantation Infertility, Female - immunology Infertility, Female - therapy Internal Medicine Menstrual Cycle - immunology Models, Immunological Obstetrics and Gynecology Pregnancy progesterone resistance Recurrence Species Specificity Transcriptome - immunology Treatment Failure |
| title | Endometrial receptivity in the eutopic endometrium of women with endometriosis—it is affected: let me show you why |
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