Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation

Really interesting new gene (RING)-finger protein 52 (RNF52), an E3 ubiquitin ligase, is found in eukaryotes from yeast to humans. Human RNF52 is known as breast cancer type 1 susceptibility protein (BRCA1)-associated protein 2 (BRAP or BRAP2). The central catalytic domain of BRAP comprises four sub...

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Veröffentlicht in:	Biochemical journal 2017-09, Vol.474 (18), p.3207-3226
Hauptverfasser:	Shoji, Shisako, Hanada, Kazuharu, Ohsawa, Noboru, Shirouzu, Mikako
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Catalytic Domain Humans Protein Interaction Domains and Motifs Sequence Homology Signal Transduction Ubiquitin - chemistry Ubiquitin - metabolism Ubiquitin-Conjugating Enzymes - metabolism Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism Ubiquitination
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