Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice

In this study, we tested the hypothesis that reduced bioavailability of tetrahydrobiopterin (BH4) is a major mechanism responsible for pathogenesis of endothelial dysfunction in cerebral microvessels of transgenic mice expressing the Swedish double mutation of human amyloid precursor protein (APP) (...

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Veröffentlicht in:	Journal of neurochemistry 2015-09, Vol.134 (6), p.1129-1138
Hauptverfasser:	Santhanam, Anantha Vijay R., d'Uscio, Livius V., He, Tongrong, Das, Pritam, Younkin, Steven G., Katusic, Zvonimir S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Protein Precursor - metabolism Animals Bioavailability Biopterins - analogs & derivatives Biopterins - metabolism Blotting, Western Brain - metabolism Disease Models, Animal endothelial dysfunction Endothelium, Vascular - metabolism Enzymes Female Humans Mice Mice, Transgenic Microvessels Neurochemistry Nitric oxide Nitric Oxide Synthase Type III - metabolism oxidative stress Oxidative Stress - physiology Pathogenesis superoxide anions tetrahydrobiopterin
Online-Zugang:	Volltext
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