Mitotic post-translational modifications of histones promote chromatin compaction in vitro

How eukaryotic chromosomes are compacted during mitosis has been a leading question in cell biology since the nineteenth century. Non-histone proteins such as condensin complexes contribute to chromosome shaping, but appear not to be necessary for mitotic chromatin compaction. Histone modifications...

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Veröffentlicht in:	Open biology 2017-09, Vol.7 (9), p.170076
Hauptverfasser:	Zhiteneva, Alisa, Bonfiglio, Juan Jose, Makarov, Alexandr, Colby, Thomas, Vagnarelli, Paola, Schirmer, Eric C., Matic, Ivan, Earnshaw, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Animals Cations, Divalent Cell Line, Tumor Chickens Chromatin Chromatin - drug effects Chromatin - metabolism Chromatin - ultrastructure Chromatin Assembly and Disassembly - drug effects Chromosome Compaction DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Histone Modifications Histones - genetics Histones - metabolism Humans Interphase - drug effects Lymphocytes - drug effects Lymphocytes - metabolism Lymphocytes - ultrastructure Magnesium - pharmacology Microscopy, Atomic Force Mitosis Mitosis - drug effects Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Nocodazole - pharmacology Phosphorylation Protein Processing, Post-Translational Tubulin Modulators - pharmacology
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