Synaptic Transmission Optimization Predicts Expression Loci of Long-Term Plasticity

Long-term modifications of neuronal connections are critical for reliable memory storage in the brain. However, their locus of expression—pre- or postsynaptic—is highly variable. Here we introduce a theoretical framework in which long-term plasticity performs an optimization of the postsynaptic resp...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2017-09, Vol.96 (1), p.177-189.e7
Hauptverfasser:	Costa, Rui Ponte, Padamsey, Zahid, D’Amour, James A., Emptage, Nigel J., Froemke, Robert C., Vogels, Tim P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals endocannabinoids excitation-inhibition balance Experiments expression loci Hippocampus Hippocampus - physiology inhibitory plasticity Long-term depression Long-Term Potentiation - physiology Long-Term Synaptic Depression - physiology long-term synaptic plasticity Models, Neurological Neocortex Neocortex - physiology Neural Inhibition - physiology Neuronal Plasticity - physiology nitric oxide Plastic properties retrograde messengers Statistics Synapses Synaptic depression Synaptic plasticity Synaptic transmission Synaptic Transmission - physiology Theory
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