Substrate Recognition of MARTX Ras/Rap1-Specific Endopeptidase

Ras/Rap1-specific endopeptidase (RRSP) is a cytotoxic effector domain of the multifunctional autoprocessing repeats-in-toxin (MARTX) toxin of highly virulent strains of Vibrio vulnificus. RRSP blocks RAS-MAPK kinase signaling by cleaving Ras and Rap1 within the switch I region between Y32 and D33. A...

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Veröffentlicht in:	Biochemistry (Easton) 2017-05, Vol.56 (21), p.2747-2757
Hauptverfasser:	Biancucci, Marco, Rabideau, Amy E., Lu, Zeyu, Loftis, Alex R., Pentelute, Bradley L., Satchell, Karla J. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Toxins - chemistry Bacterial Toxins - metabolism Endopeptidases - chemistry Endopeptidases - metabolism Humans Models, Molecular rap1 GTP-Binding Proteins - chemistry rap1 GTP-Binding Proteins - metabolism ras Proteins - chemistry ras Proteins - metabolism Substrate Specificity Vibrio vulnificus - enzymology
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