Cbfβ2 deficiency preserves Langerhans cell precursors by lack of selective TGFβ receptor signaling

The mouse Langerhans cell (LC) network is established through the differentiation of embryonic LC precursors. BMP7 and TGFβ1 initiate cellular signaling that is essential for inducing LC differentiation and preserving LCs in a quiescent state, respectively. Here we show that loss of Cbfβ2, one of tw...

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Veröffentlicht in:	The Journal of experimental medicine 2017-10, Vol.214 (10), p.2933-2946
Hauptverfasser:	Tenno, Mari, Shiroguchi, Katsuyuki, Muroi, Sawako, Kawakami, Eiryo, Koseki, Keita, Kryukov, Kirill, Imanishi, Tadashi, Ginhoux, Florent, Taniuchi, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Animals Bone Morphogenetic Protein 7 - physiology Bone Morphogenetic Protein Receptors, Type I - physiology CBFB gene Cell Differentiation - physiology Core Binding Factor beta Subunit - deficiency Core Binding Factor beta Subunit - physiology Differentiation Embryos Epidermis Female Flow Cytometry Homeostasis Langerhans Cells - physiology Male Mice Mice, Inbred C57BL Neonates Protein Isoforms Real-Time Polymerase Chain Reaction Receptors, Transforming Growth Factor beta - physiology Residential development Ribonucleic acid RNA Signal Transduction - physiology Signaling Skin Transforming growth factor-b1
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