Use of Digital Pupillometry to Measure Sedative Response to Propofol
Digital pupillometry (DP) accurately and precisely measures pupillary responses. Little is known about using DP to measure the sedative effect of isolated propofol administration. We conducted a cross-sectional study of 19 adults undergoing moderate sedation with propofol during which we measured pu...
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| Veröffentlicht in: | The Ochsner journal 2017-01, Vol.17 (3), p.250-253 |
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| container_title | The Ochsner journal |
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| creator | Haddock, Jody H Mercante, Donald E Paccione, Rose Breaux, Jacob L Jolley, Sarah E Johnson, Jessica L Connolly, Sean E deBoisblanc, Bennett P |
| description | Digital pupillometry (DP) accurately and precisely measures pupillary responses. Little is known about using DP to measure the sedative effect of isolated propofol administration.
We conducted a cross-sectional study of 19 adults undergoing moderate sedation with propofol during which we measured pupillary changes using DP.
Maximum and minimum pupillary diameters decreased significantly with propofol (mean change from baseline to procedural termination -1.24 mm, standard error [SE] 0.25 and -0.79 mm, SE 0.13, respectively;
≤0.001 for both). Mean constriction velocity decreased by 0.84 mm/s between baseline and procedural termination
0.001). Pupillary latency increased significantly between baseline and induction (mean change 0.016 seconds, SE 0.007;
=0.04) but was not significantly different at other time points.
We speculate that DP may be a useful tool to monitor propofol sedation. |
| doi_str_mv | 10.1043/1524-5012-17.3.250 |
| format | Article |
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We conducted a cross-sectional study of 19 adults undergoing moderate sedation with propofol during which we measured pupillary changes using DP.
Maximum and minimum pupillary diameters decreased significantly with propofol (mean change from baseline to procedural termination -1.24 mm, standard error [SE] 0.25 and -0.79 mm, SE 0.13, respectively;
≤0.001 for both). Mean constriction velocity decreased by 0.84 mm/s between baseline and procedural termination
0.001). Pupillary latency increased significantly between baseline and induction (mean change 0.016 seconds, SE 0.007;
=0.04) but was not significantly different at other time points.
We speculate that DP may be a useful tool to monitor propofol sedation.</description><identifier>ISSN: 1524-5012</identifier><identifier>DOI: 10.1043/1524-5012-17.3.250</identifier><identifier>PMID: 29026357</identifier><language>eng</language><publisher>United States: Ochsner Clinic Foundation Academic Center - Publishing Services</publisher><subject>Anesthesia ; Anesthesiology ; Automation ; Colonoscopy ; Data collection ; Intensive care ; Lighting ; Neurosciences ; Original Research ; Patients ; Statistical analysis ; Validity ; Velocity ; Ventilators</subject><ispartof>The Ochsner journal, 2017-01, Vol.17 (3), p.250-253</ispartof><rights>Copyright © 2017. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at http://www.ochsnerjournal.org/content/permissions</rights><rights>Academic Division of Ochsner Clinic Foundation 2017 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625983/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625983/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29026357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haddock, Jody H</creatorcontrib><creatorcontrib>Mercante, Donald E</creatorcontrib><creatorcontrib>Paccione, Rose</creatorcontrib><creatorcontrib>Breaux, Jacob L</creatorcontrib><creatorcontrib>Jolley, Sarah E</creatorcontrib><creatorcontrib>Johnson, Jessica L</creatorcontrib><creatorcontrib>Connolly, Sean E</creatorcontrib><creatorcontrib>deBoisblanc, Bennett P</creatorcontrib><title>Use of Digital Pupillometry to Measure Sedative Response to Propofol</title><title>The Ochsner journal</title><addtitle>Ochsner J</addtitle><description>Digital pupillometry (DP) accurately and precisely measures pupillary responses. Little is known about using DP to measure the sedative effect of isolated propofol administration.
We conducted a cross-sectional study of 19 adults undergoing moderate sedation with propofol during which we measured pupillary changes using DP.
Maximum and minimum pupillary diameters decreased significantly with propofol (mean change from baseline to procedural termination -1.24 mm, standard error [SE] 0.25 and -0.79 mm, SE 0.13, respectively;
≤0.001 for both). Mean constriction velocity decreased by 0.84 mm/s between baseline and procedural termination
0.001). Pupillary latency increased significantly between baseline and induction (mean change 0.016 seconds, SE 0.007;
=0.04) but was not significantly different at other time points.
We speculate that DP may be a useful tool to monitor propofol sedation.</description><subject>Anesthesia</subject><subject>Anesthesiology</subject><subject>Automation</subject><subject>Colonoscopy</subject><subject>Data collection</subject><subject>Intensive care</subject><subject>Lighting</subject><subject>Neurosciences</subject><subject>Original Research</subject><subject>Patients</subject><subject>Statistical analysis</subject><subject>Validity</subject><subject>Velocity</subject><subject>Ventilators</subject><issn>1524-5012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkM1Lw0AQxfeg2Fr9BzxIwIuX1P2aTXIRpPULKha157BJJjVlk427SaH_vQG1qKeBeb95vDeEnDE6ZVSKKwZchkAZD1k0FVMO9ICM98sROfZ-Q6mkIPkRGfGEciUgGpP5ymNgy2BeratOm2DZt5UxtsbO7YLOBk-ofe8weMVCd9UWgxf0rW2Go0FcOtva0poTclhq4_H0e07I6u72bfYQLp7vH2c3i7DliexCyCBTBWQCmaZKScVLCormkeAxCqSSo2BZIjMKcQJFWWYyzykFVmaslIqKCbn-8m37rMYix6Zz2qStq2rtdqnVVfpXaar3dG23KSgOSSwGg8tvA2c_evRdWlc-R2N0g7b3KUuADWwU8wG9-IdubO-aoV7KGQxAHIt4oM5_J9pH-Xmw-AQJLnr2</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Haddock, Jody H</creator><creator>Mercante, Donald E</creator><creator>Paccione, Rose</creator><creator>Breaux, Jacob L</creator><creator>Jolley, Sarah E</creator><creator>Johnson, Jessica L</creator><creator>Connolly, Sean E</creator><creator>deBoisblanc, Bennett P</creator><general>Ochsner Clinic Foundation Academic Center - Publishing Services</general><general>the Academic Division of Ochsner Clinic Foundation</general><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Use of Digital Pupillometry to Measure Sedative Response to Propofol</title><author>Haddock, Jody H ; 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Little is known about using DP to measure the sedative effect of isolated propofol administration.
We conducted a cross-sectional study of 19 adults undergoing moderate sedation with propofol during which we measured pupillary changes using DP.
Maximum and minimum pupillary diameters decreased significantly with propofol (mean change from baseline to procedural termination -1.24 mm, standard error [SE] 0.25 and -0.79 mm, SE 0.13, respectively;
≤0.001 for both). Mean constriction velocity decreased by 0.84 mm/s between baseline and procedural termination
0.001). Pupillary latency increased significantly between baseline and induction (mean change 0.016 seconds, SE 0.007;
=0.04) but was not significantly different at other time points.
We speculate that DP may be a useful tool to monitor propofol sedation.</abstract><cop>United States</cop><pub>Ochsner Clinic Foundation Academic Center - Publishing Services</pub><pmid>29026357</pmid><doi>10.1043/1524-5012-17.3.250</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anesthesia Anesthesiology Automation Colonoscopy Data collection Intensive care Lighting Neurosciences Original Research Patients Statistical analysis Validity Velocity Ventilators |
| title | Use of Digital Pupillometry to Measure Sedative Response to Propofol |
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