E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation

α-Synuclein (aSyn) is the main driver of neurodegenerative diseases known as “synucleinopathies,” but the mechanisms underlying this toxicity remain poorly understood. To investigate aSyn toxic mechanisms, we have developed a primary neuronal model in which a longitudinal survival analysis can be pe...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-09, Vol.114 (39), p.E8274-E8283
Hauptverfasser:	Iñigo-Marco, Ignacio, Valencia, Miguel, Larrea, Laura, Bugallo, Ricardo, Martínez-Goikoetxea, Mikel, Zuriguel, Iker, Arrasate, Montserrat
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Biological Sciences Mutation Neurodegenerative diseases Neurological diseases Neurons Phosphorylation PNAS Plus Protein turnover Proteins Serine Survival Survival analysis Synuclein Toxicity
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