Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells

Tumor cell invasion involves targeted localization of proteins required for interactions with the extracellular matrix and for proteolysis. The localization of many proteins during these cell–extracellular matrix interactions relies on membrane trafficking mediated in part by SNAREs. The SNARE prote...

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Veröffentlicht in:	The Journal of biological chemistry 2017-09, Vol.292 (39), p.16199-16210
Hauptverfasser:	Brasher, Megan I., Martynowicz, David M., Grafinger, Olivia R., Hucik, Andrea, Shanks-Skinner, Emma, Uniacke, James, Coppolino, Marc G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Binding, Competitive Cell Biology cell invasion Cell Line, Tumor epidermal growth factor receptor (EGFR) ErbB Receptors - metabolism Extracellular Matrix - metabolism Extracellular Matrix - pathology Fibrosarcoma - metabolism Fibrosarcoma - pathology Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans invadopodia matrix metalloproteinase (MMP) Matrix Metalloproteinase 14 - metabolism Munc18 Proteins - antagonists & inhibitors Munc18 Proteins - chemistry Munc18 Proteins - genetics Munc18 Proteins - metabolism Munc18c Neoplasm Invasiveness Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Podosomes - metabolism Podosomes - pathology Protein Interaction Domains and Motifs Protein Multimerization Protein Transport Qa-SNARE Proteins - chemistry Qa-SNARE Proteins - genetics Qa-SNARE Proteins - metabolism Qb-SNARE Proteins - antagonists & inhibitors Qb-SNARE Proteins - chemistry Qb-SNARE Proteins - metabolism Qc-SNARE Proteins - antagonists & inhibitors Qc-SNARE Proteins - chemistry Qc-SNARE Proteins - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism RNA Interference syntaxin4 trafficking Vesicle-Associated Membrane Protein 2 - antagonists & inhibitors Vesicle-Associated Membrane Protein 2 - chemistry Vesicle-Associated Membrane Protein 2 - metabolism
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