The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa Acquisita

The inflammatory form of epidermolysis bullosa acquisita is caused by autoantibodies against type VII collagen (C7), a component of the dermal-epidermal junction. We have previously shown that myeloid Src family kinases mediate skin inflammation triggered by anti-C7 antibodies. Here we identify the...

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Veröffentlicht in:	Journal of investigative dermatology 2017-10, Vol.137 (10), p.2131-2139
Hauptverfasser:	Németh, Tamás, Virtic, Oana, Sitaru, Cassian, Mócsai, Attila
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - immunology Cells, Cultured Complement C7 - immunology Complement C7 - metabolism Disease Models, Animal DNA - genetics DNA Mutational Analysis Epidermolysis Bullosa Acquisita - genetics Epidermolysis Bullosa Acquisita - metabolism Epidermolysis Bullosa Acquisita - pathology Mice Mutation Neutrophil Infiltration Neutrophils - immunology Original Skin - immunology Skin - pathology Syk Kinase - genetics Syk Kinase - metabolism
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