The vascular basement membrane in the healthy and pathological brain
The vascular basement membrane contributes to the integrity of the blood-brain barrier (BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive support from pericytes embedded in the vascular basement membrane and from astrocyte endfeet. The vascular basement membrane f...
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Veröffentlicht in: | Journal of Cerebral Blood Flow & Metabolism 2017-10, Vol.37 (10), p.3300-3317 |
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description | The vascular basement membrane contributes to the integrity of the blood-brain barrier (BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive support from pericytes embedded in the vascular basement membrane and from astrocyte endfeet. The vascular basement membrane forms a three-dimensional protein network predominantly composed of laminin, collagen IV, nidogen, and heparan sulfate proteoglycans that mutually support interactions between BCECs, pericytes, and astrocytes. Major changes in the molecular composition of the vascular basement membrane are observed in acute and chronic neuropathological settings. In the present review, we cover the significance of the vascular basement membrane in the healthy and pathological brain. In stroke, loss of BBB integrity is accompanied by upregulation of proteolytic enzymes and degradation of vascular basement membrane proteins. There is yet no causal relationship between expression or activity of matrix proteases and the degradation of vascular matrix proteins in vivo. In Alzheimer’s disease, changes in the vascular basement membrane include accumulation of Aβ, composite changes, and thickening. The physical properties of the vascular basement membrane carry the potential of obstructing drug delivery to the brain, e.g. thickening of the basement membrane can affect drug delivery to the brain, especially the delivery of nanoparticles. |
doi_str_mv | 10.1177/0271678X17722436 |
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In Alzheimer’s disease, changes in the vascular basement membrane include accumulation of Aβ, composite changes, and thickening. 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The BCECs receive support from pericytes embedded in the vascular basement membrane and from astrocyte endfeet. The vascular basement membrane forms a three-dimensional protein network predominantly composed of laminin, collagen IV, nidogen, and heparan sulfate proteoglycans that mutually support interactions between BCECs, pericytes, and astrocytes. Major changes in the molecular composition of the vascular basement membrane are observed in acute and chronic neuropathological settings. In the present review, we cover the significance of the vascular basement membrane in the healthy and pathological brain. In stroke, loss of BBB integrity is accompanied by upregulation of proteolytic enzymes and degradation of vascular basement membrane proteins. There is yet no causal relationship between expression or activity of matrix proteases and the degradation of vascular matrix proteins in vivo. In Alzheimer’s disease, changes in the vascular basement membrane include accumulation of Aβ, composite changes, and thickening. The physical properties of the vascular basement membrane carry the potential of obstructing drug delivery to the brain, e.g. thickening of the basement membrane can affect drug delivery to the brain, especially the delivery of nanoparticles.</description><subject>Basement Membrane - chemistry</subject><subject>Basement Membrane - cytology</subject><subject>Basement Membrane - pathology</subject><subject>Blood-Brain Barrier - cytology</subject><subject>Brain - blood supply</subject><subject>Brain Diseases - pathology</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - pathology</subject><subject>Humans</subject><subject>Review</subject><issn>0271-678X</issn><issn>1559-7016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kElLAzEUx4MotlbvnmS-wGiWydKLIHWFgpcK3sKbzEtnyixlMi347U2pFhU8vcB_eS8_Qi4ZvWZM6xvKNVPavMc355lQR2TMpJymmjJ1TMY7Od3pI3IWwopSaoSUp2TEjZaCUTkm94sSky0Et6mhT3II2GA7JA02eQ8tJlWbDNFRItRD-ZFAWyRrGMqu7paVgzqJrqo9Jyce6oAXX3NC3h4fFrPndP769DK7m6dOZnpI0aFhUHg0AjxKZXJntCuyKaBTxnBhFHMenMpF_I1HzqUE6hx33ptMoJiQ233vepM3WLh4aQ-1XfdVA_2H7aCyv5W2Ku2y21qpIp3pNBbQfYHruxB69Icso3ZH1P4lGiNXP3ceAt8IoyHdGwIs0a66Td9GBv8XfgJYFID_</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Thomsen, Maj S</creator><creator>Routhe, Lisa J</creator><creator>Moos, Torben</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20171001</creationdate><title>The vascular basement membrane in the healthy and pathological brain</title><author>Thomsen, Maj S ; Routhe, Lisa J ; Moos, Torben</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-ece81adfe83afe568bc87cd49aec68823861cfac6b3224fe2255a0cc2cff843e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Basement Membrane - chemistry</topic><topic>Basement Membrane - cytology</topic><topic>Basement Membrane - pathology</topic><topic>Blood-Brain Barrier - cytology</topic><topic>Brain - blood supply</topic><topic>Brain Diseases - pathology</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - pathology</topic><topic>Humans</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomsen, Maj S</creatorcontrib><creatorcontrib>Routhe, Lisa J</creatorcontrib><creatorcontrib>Moos, Torben</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Cerebral Blood Flow & Metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomsen, Maj S</au><au>Routhe, Lisa J</au><au>Moos, Torben</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The vascular basement membrane in the healthy and pathological brain</atitle><jtitle>Journal of Cerebral Blood Flow & Metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>37</volume><issue>10</issue><spage>3300</spage><epage>3317</epage><pages>3300-3317</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><abstract>The vascular basement membrane contributes to the integrity of the blood-brain barrier (BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive support from pericytes embedded in the vascular basement membrane and from astrocyte endfeet. The vascular basement membrane forms a three-dimensional protein network predominantly composed of laminin, collagen IV, nidogen, and heparan sulfate proteoglycans that mutually support interactions between BCECs, pericytes, and astrocytes. Major changes in the molecular composition of the vascular basement membrane are observed in acute and chronic neuropathological settings. In the present review, we cover the significance of the vascular basement membrane in the healthy and pathological brain. In stroke, loss of BBB integrity is accompanied by upregulation of proteolytic enzymes and degradation of vascular basement membrane proteins. There is yet no causal relationship between expression or activity of matrix proteases and the degradation of vascular matrix proteins in vivo. In Alzheimer’s disease, changes in the vascular basement membrane include accumulation of Aβ, composite changes, and thickening. The physical properties of the vascular basement membrane carry the potential of obstructing drug delivery to the brain, e.g. thickening of the basement membrane can affect drug delivery to the brain, especially the delivery of nanoparticles.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>28753105</pmid><doi>10.1177/0271678X17722436</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SAGE Complete A-Z List; PubMed Central |
subjects | Basement Membrane - chemistry Basement Membrane - cytology Basement Membrane - pathology Blood-Brain Barrier - cytology Brain - blood supply Brain Diseases - pathology Endothelium, Vascular - cytology Endothelium, Vascular - pathology Humans Review |
title | The vascular basement membrane in the healthy and pathological brain |
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