Convergence of Implementation Science, Precision Medicine, and the Learning Health Care System: A New Model for Biomedical Research

Since the start of the Human Genome Project 25 years ago, basic discoveries related to genomics and other "-omic" fields have continued to advance exponentially. This progress has facilitated the 2015 launch of the US Precision Medicine Initiative (PMI). The PMI is intended to merge genomi...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2016-05, Vol.315 (18), p.1941-1942
Hauptverfasser:	Chambers, David A, Feero, W. Gregory, Khoury, Muin J
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Sprache:	eng
Schlagworte:	Biomedical research Biomedical Research - organization & administration Biomedical Research - trends Biomedical Technology - organization & administration Biomedical Technology - trends Cell Phone Delivery of Health Care - organization & administration Delivery of Health Care - trends Evidence-Based Practice - trends Genomics Genomics - trends Health care delivery Humans Initiatives Medical technology Mobile Applications - trends Models, Theoretical Precision Medicine - trends
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container_end_page	1942
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container_title	JAMA : the journal of the American Medical Association
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creator	Chambers, David A Feero, W. Gregory Khoury, Muin J
description	Since the start of the Human Genome Project 25 years ago, basic discoveries related to genomics and other "-omic" fields have continued to advance exponentially. This progress has facilitated the 2015 launch of the US Precision Medicine Initiative (PMI). The PMI is intended to merge genomic, biological, behavioral, environmental, and other data on individuals to identify drivers of health that might support personalized health care decision making. In the cancer domain, for example, recognition of both inherited genetic susceptibility (eg, Lynch syndrome for colorectal cancer, and BRCA1/2 for breast cancer) and cancer genome sequence alterations that can pinpoint therapeutic agents (eg, National Cancer Institute's MATCH trials) has the potential to make clinical decisions more personalized both in prevention and treatment. The "National Cancer Moonshot Initiative" seeks to rapidly scale up these efforts. Here, Chambers et al discuss convergence of implementation science, precision medicine, and the learning health care system, a new model for biomedical research.
doi_str_mv	10.1001/jama.2016.3867
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subjects	Biomedical research Biomedical Research - organization & administration Biomedical Research - trends Biomedical Technology - organization & administration Biomedical Technology - trends Cell Phone Delivery of Health Care - organization & administration Delivery of Health Care - trends Evidence-Based Practice - trends Genomics Genomics - trends Health care delivery Humans Initiatives Medical technology Mobile Applications - trends Models, Theoretical Precision Medicine - trends
title	Convergence of Implementation Science, Precision Medicine, and the Learning Health Care System: A New Model for Biomedical Research
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