LncRNA‐PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis
Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosi...
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| creator | Wu, Xiang‐Song Wang, Fang Li, Huai‐Feng Hu, Yun‐Ping Jiang, Lin Zhang, Fei Li, Mao‐Lan Wang, Xu‐An Jin, Yun‐Peng Zhang, Yi‐Jian Lu, Wei Wu, Wen‐Guang Shu, Yi‐Jun Weng, Hao Cao, Yang Bao, Run‐Fa Liang, Hai‐Bin Wang, Zheng Zhang, Yi‐Chi Gong, Wei Zheng, Lei Sun, Shu‐Han Liu, Ying‐Bin |
| description | Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis‐associated gallbladder cancer lncRNA (lncRNA‐PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA‐PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA‐PAGBC competitively binds to the tumour suppressive microRNAs miR‐133b and miR‐511. This competitive role of lncRNA‐PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA‐PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.
Synopsis
Long noncoding RNAs play roles in the development and progression of many cancers. In this study the lncRNA PAGBC is identified as promoting tumorigenesis in human gallbladder cancer by competitive binding to the tumour suppressive microRNAs miR‐133b and miR‐511.
LncRNA‐PAGBC is up‐regulated in GBC and increased levels associate with poor prognosis.
LncRNA‐PAGBC promotes tumour growth and metastasis, and activates AKT/mTOR signaling by competitively binding to mirR‐133b and mirR‐511.
LncRNA‐PAGBC interacts with and is stabilized by the polyadenylate binding protein PABPC1.
Graphical Abstract
Long noncoding RNAs play roles in the development and progression of many cancers. In this study the lncRNA PAGBC is identified as promoting tumorigenesis in human gallbladder cancer by competitive binding to the tumour suppressive microRNAs miR‐133b and miR‐511. |
| doi_str_mv | 10.15252/embr.201744147 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_C6C</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5623869</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1945033230</sourcerecordid><originalsourceid>FETCH-LOGICAL-p3867-8a4d4e235552a925c9d837ad8b56cf646b2eabda425adc5369f68116c722fdc93</originalsourceid><addsrcrecordid>eNptkc9LHDEcxUOp6Go991YGeullNb-T6aGwLroKq1tEobeQSbLbkZnJNJlR9uaf4N_oX2LWXRdbCoEkvM_38ZIHwGcEjxDDDB-7ughHGCJBKaLiAxggyvMhQUJ-3JwxRr_2wH6MdxBClgu5C_awlFIQjAZgNm3M9dXo-fHp52hyMs606WKm08rq0gSfpCy2vlm4TDc2a4OvfedittBVVVTaWheyrq99KBeucbGMn8DOXFfRHW72A3B7dnozPh9OZ5OL8Wg6bInkYig1tdRhwhjDOsfM5FYSoa0sGDdzTnmBnS6spphpaxjh-ZxLhLgRGM-tyckB-LH2bfuidta4pgu6Um0oax2WyutS_a005W-18PeKcZwSrAy-bQyC_9O72Km6jMZVlW6c76NCORGMQIFW6Nd_0DvfhyY9L1GUQUIwgYn68j7RNsrbXyfg-xp4KCu33OoIqtcq1apKta1SnV6eXG9vaRiuh2OaS3WEdxn-b0BeAOZMoss</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1945033230</pqid></control><display><type>article</type><title>LncRNA‐PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis</title><source>Springer Nature OA Free Journals</source><creator>Wu, Xiang‐Song ; Wang, Fang ; Li, Huai‐Feng ; Hu, Yun‐Ping ; Jiang, Lin ; Zhang, Fei ; Li, Mao‐Lan ; Wang, Xu‐An ; Jin, Yun‐Peng ; Zhang, Yi‐Jian ; Lu, Wei ; Wu, Wen‐Guang ; Shu, Yi‐Jun ; Weng, Hao ; Cao, Yang ; Bao, Run‐Fa ; Liang, Hai‐Bin ; Wang, Zheng ; Zhang, Yi‐Chi ; Gong, Wei ; Zheng, Lei ; Sun, Shu‐Han ; Liu, Ying‐Bin</creator><creatorcontrib>Wu, Xiang‐Song ; Wang, Fang ; Li, Huai‐Feng ; Hu, Yun‐Ping ; Jiang, Lin ; Zhang, Fei ; Li, Mao‐Lan ; Wang, Xu‐An ; Jin, Yun‐Peng ; Zhang, Yi‐Jian ; Lu, Wei ; Wu, Wen‐Guang ; Shu, Yi‐Jun ; Weng, Hao ; Cao, Yang ; Bao, Run‐Fa ; Liang, Hai‐Bin ; Wang, Zheng ; Zhang, Yi‐Chi ; Gong, Wei ; Zheng, Lei ; Sun, Shu‐Han ; Liu, Ying‐Bin</creatorcontrib><description>Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis‐associated gallbladder cancer lncRNA (lncRNA‐PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA‐PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA‐PAGBC competitively binds to the tumour suppressive microRNAs miR‐133b and miR‐511. This competitive role of lncRNA‐PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA‐PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.
Synopsis
Long noncoding RNAs play roles in the development and progression of many cancers. In this study the lncRNA PAGBC is identified as promoting tumorigenesis in human gallbladder cancer by competitive binding to the tumour suppressive microRNAs miR‐133b and miR‐511.
LncRNA‐PAGBC is up‐regulated in GBC and increased levels associate with poor prognosis.
LncRNA‐PAGBC promotes tumour growth and metastasis, and activates AKT/mTOR signaling by competitively binding to mirR‐133b and mirR‐511.
LncRNA‐PAGBC interacts with and is stabilized by the polyadenylate binding protein PABPC1.
Graphical Abstract
Long noncoding RNAs play roles in the development and progression of many cancers. In this study the lncRNA PAGBC is identified as promoting tumorigenesis in human gallbladder cancer by competitive binding to the tumour suppressive microRNAs miR‐133b and miR‐511.</description><identifier>ISSN: 1469-221X</identifier><identifier>ISSN: 1469-3178</identifier><identifier>EISSN: 1469-3178</identifier><identifier>DOI: 10.15252/embr.201744147</identifier><identifier>PMID: 28887321</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>AKT protein ; Binding ; Cancer ; Carcinogenesis - genetics ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic ; ceRNA ; EMBO03 ; EMBO36 ; EMBO37 ; Functional analysis ; Gallbladder ; Gallbladder - physiopathology ; Gallbladder cancer ; Gallbladder Neoplasms - genetics ; Gallbladder Neoplasms - pathology ; Gene Expression Regulation, Neoplastic ; Humans ; lncRNA ; Metastases ; Metastasis ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; Neoplasm Metastasis ; PAGBC ; Pathogenesis ; Polyadenylation ; Prognosis ; Proto-Oncogene Proteins c-akt - metabolism ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - genetics ; TOR protein ; TOR Serine-Threonine Kinases - metabolism ; Tumorigenesis ; Tumors</subject><ispartof>EMBO reports, 2017-10, Vol.18 (10), p.1837-1853</ispartof><rights>The Authors 2017</rights><rights>2017 The Authors</rights><rights>2017 The Authors.</rights><rights>2017 EMBO</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-4163-2541 ; 0000-0002-1075-1890 ; 0000-0001-6641-6197</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623869/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623869/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27901,27902,41096,42165,45550,45551,46384,46808,51551,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://doi.org/10.15252/embr.201744147$$EView_record_in_Springer_Nature$$FView_record_in_$$GSpringer_Nature</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28887321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Xiang‐Song</creatorcontrib><creatorcontrib>Wang, Fang</creatorcontrib><creatorcontrib>Li, Huai‐Feng</creatorcontrib><creatorcontrib>Hu, Yun‐Ping</creatorcontrib><creatorcontrib>Jiang, Lin</creatorcontrib><creatorcontrib>Zhang, Fei</creatorcontrib><creatorcontrib>Li, Mao‐Lan</creatorcontrib><creatorcontrib>Wang, Xu‐An</creatorcontrib><creatorcontrib>Jin, Yun‐Peng</creatorcontrib><creatorcontrib>Zhang, Yi‐Jian</creatorcontrib><creatorcontrib>Lu, Wei</creatorcontrib><creatorcontrib>Wu, Wen‐Guang</creatorcontrib><creatorcontrib>Shu, Yi‐Jun</creatorcontrib><creatorcontrib>Weng, Hao</creatorcontrib><creatorcontrib>Cao, Yang</creatorcontrib><creatorcontrib>Bao, Run‐Fa</creatorcontrib><creatorcontrib>Liang, Hai‐Bin</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><creatorcontrib>Zhang, Yi‐Chi</creatorcontrib><creatorcontrib>Gong, Wei</creatorcontrib><creatorcontrib>Zheng, Lei</creatorcontrib><creatorcontrib>Sun, Shu‐Han</creatorcontrib><creatorcontrib>Liu, Ying‐Bin</creatorcontrib><title>LncRNA‐PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis</title><title>EMBO reports</title><addtitle>EMBO Rep</addtitle><addtitle>EMBO Rep</addtitle><description>Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis‐associated gallbladder cancer lncRNA (lncRNA‐PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA‐PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA‐PAGBC competitively binds to the tumour suppressive microRNAs miR‐133b and miR‐511. This competitive role of lncRNA‐PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA‐PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.
Synopsis
Long noncoding RNAs play roles in the development and progression of many cancers. In this study the lncRNA PAGBC is identified as promoting tumorigenesis in human gallbladder cancer by competitive binding to the tumour suppressive microRNAs miR‐133b and miR‐511.
LncRNA‐PAGBC is up‐regulated in GBC and increased levels associate with poor prognosis.
LncRNA‐PAGBC promotes tumour growth and metastasis, and activates AKT/mTOR signaling by competitively binding to mirR‐133b and mirR‐511.
LncRNA‐PAGBC interacts with and is stabilized by the polyadenylate binding protein PABPC1.
Graphical Abstract
Long noncoding RNAs play roles in the development and progression of many cancers. In this study the lncRNA PAGBC is identified as promoting tumorigenesis in human gallbladder cancer by competitive binding to the tumour suppressive microRNAs miR‐133b and miR‐511.</description><subject>AKT protein</subject><subject>Binding</subject><subject>Cancer</subject><subject>Carcinogenesis - genetics</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Cell Transformation, Neoplastic</subject><subject>ceRNA</subject><subject>EMBO03</subject><subject>EMBO36</subject><subject>EMBO37</subject><subject>Functional analysis</subject><subject>Gallbladder</subject><subject>Gallbladder - physiopathology</subject><subject>Gallbladder cancer</subject><subject>Gallbladder Neoplasms - genetics</subject><subject>Gallbladder Neoplasms - pathology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>lncRNA</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>Neoplasm Metastasis</subject><subject>PAGBC</subject><subject>Pathogenesis</subject><subject>Polyadenylation</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - genetics</subject><subject>TOR protein</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>1469-221X</issn><issn>1469-3178</issn><issn>1469-3178</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc9LHDEcxUOp6Go991YGeullNb-T6aGwLroKq1tEobeQSbLbkZnJNJlR9uaf4N_oX2LWXRdbCoEkvM_38ZIHwGcEjxDDDB-7ughHGCJBKaLiAxggyvMhQUJ-3JwxRr_2wH6MdxBClgu5C_awlFIQjAZgNm3M9dXo-fHp52hyMs606WKm08rq0gSfpCy2vlm4TDc2a4OvfedittBVVVTaWheyrq99KBeucbGMn8DOXFfRHW72A3B7dnozPh9OZ5OL8Wg6bInkYig1tdRhwhjDOsfM5FYSoa0sGDdzTnmBnS6spphpaxjh-ZxLhLgRGM-tyckB-LH2bfuidta4pgu6Um0oax2WyutS_a005W-18PeKcZwSrAy-bQyC_9O72Km6jMZVlW6c76NCORGMQIFW6Nd_0DvfhyY9L1GUQUIwgYn68j7RNsrbXyfg-xp4KCu33OoIqtcq1apKta1SnV6eXG9vaRiuh2OaS3WEdxn-b0BeAOZMoss</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Wu, Xiang‐Song</creator><creator>Wang, Fang</creator><creator>Li, Huai‐Feng</creator><creator>Hu, Yun‐Ping</creator><creator>Jiang, Lin</creator><creator>Zhang, Fei</creator><creator>Li, Mao‐Lan</creator><creator>Wang, Xu‐An</creator><creator>Jin, Yun‐Peng</creator><creator>Zhang, Yi‐Jian</creator><creator>Lu, Wei</creator><creator>Wu, Wen‐Guang</creator><creator>Shu, Yi‐Jun</creator><creator>Weng, Hao</creator><creator>Cao, Yang</creator><creator>Bao, Run‐Fa</creator><creator>Liang, Hai‐Bin</creator><creator>Wang, Zheng</creator><creator>Zhang, Yi‐Chi</creator><creator>Gong, Wei</creator><creator>Zheng, Lei</creator><creator>Sun, Shu‐Han</creator><creator>Liu, Ying‐Bin</creator><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4163-2541</orcidid><orcidid>https://orcid.org/0000-0002-1075-1890</orcidid><orcidid>https://orcid.org/0000-0001-6641-6197</orcidid></search><sort><creationdate>201710</creationdate><title>LncRNA‐PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis</title><author>Wu, Xiang‐Song ; Wang, Fang ; Li, Huai‐Feng ; Hu, Yun‐Ping ; Jiang, Lin ; Zhang, Fei ; Li, Mao‐Lan ; Wang, Xu‐An ; Jin, Yun‐Peng ; Zhang, Yi‐Jian ; Lu, Wei ; Wu, Wen‐Guang ; Shu, Yi‐Jun ; Weng, Hao ; Cao, Yang ; Bao, Run‐Fa ; Liang, Hai‐Bin ; Wang, Zheng ; Zhang, Yi‐Chi ; Gong, Wei ; Zheng, Lei ; Sun, Shu‐Han ; Liu, Ying‐Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3867-8a4d4e235552a925c9d837ad8b56cf646b2eabda425adc5369f68116c722fdc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>AKT protein</topic><topic>Binding</topic><topic>Cancer</topic><topic>Carcinogenesis - genetics</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Cell Transformation, Neoplastic</topic><topic>ceRNA</topic><topic>EMBO03</topic><topic>EMBO36</topic><topic>EMBO37</topic><topic>Functional analysis</topic><topic>Gallbladder</topic><topic>Gallbladder - physiopathology</topic><topic>Gallbladder cancer</topic><topic>Gallbladder Neoplasms - genetics</topic><topic>Gallbladder Neoplasms - pathology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>lncRNA</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>miRNA</topic><topic>Neoplasm Metastasis</topic><topic>PAGBC</topic><topic>Pathogenesis</topic><topic>Polyadenylation</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Long Noncoding - genetics</topic><topic>TOR protein</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Xiang‐Song</creatorcontrib><creatorcontrib>Wang, Fang</creatorcontrib><creatorcontrib>Li, Huai‐Feng</creatorcontrib><creatorcontrib>Hu, Yun‐Ping</creatorcontrib><creatorcontrib>Jiang, Lin</creatorcontrib><creatorcontrib>Zhang, Fei</creatorcontrib><creatorcontrib>Li, Mao‐Lan</creatorcontrib><creatorcontrib>Wang, Xu‐An</creatorcontrib><creatorcontrib>Jin, Yun‐Peng</creatorcontrib><creatorcontrib>Zhang, Yi‐Jian</creatorcontrib><creatorcontrib>Lu, Wei</creatorcontrib><creatorcontrib>Wu, Wen‐Guang</creatorcontrib><creatorcontrib>Shu, Yi‐Jun</creatorcontrib><creatorcontrib>Weng, Hao</creatorcontrib><creatorcontrib>Cao, Yang</creatorcontrib><creatorcontrib>Bao, Run‐Fa</creatorcontrib><creatorcontrib>Liang, Hai‐Bin</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><creatorcontrib>Zhang, Yi‐Chi</creatorcontrib><creatorcontrib>Gong, Wei</creatorcontrib><creatorcontrib>Zheng, Lei</creatorcontrib><creatorcontrib>Sun, Shu‐Han</creatorcontrib><creatorcontrib>Liu, Ying‐Bin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>EMBO reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Wu, Xiang‐Song</au><au>Wang, Fang</au><au>Li, Huai‐Feng</au><au>Hu, Yun‐Ping</au><au>Jiang, Lin</au><au>Zhang, Fei</au><au>Li, Mao‐Lan</au><au>Wang, Xu‐An</au><au>Jin, Yun‐Peng</au><au>Zhang, Yi‐Jian</au><au>Lu, Wei</au><au>Wu, Wen‐Guang</au><au>Shu, Yi‐Jun</au><au>Weng, Hao</au><au>Cao, Yang</au><au>Bao, Run‐Fa</au><au>Liang, Hai‐Bin</au><au>Wang, Zheng</au><au>Zhang, Yi‐Chi</au><au>Gong, Wei</au><au>Zheng, Lei</au><au>Sun, Shu‐Han</au><au>Liu, Ying‐Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LncRNA‐PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis</atitle><jtitle>EMBO reports</jtitle><stitle>EMBO Rep</stitle><addtitle>EMBO Rep</addtitle><date>2017-10</date><risdate>2017</risdate><volume>18</volume><issue>10</issue><spage>1837</spage><epage>1853</epage><pages>1837-1853</pages><issn>1469-221X</issn><issn>1469-3178</issn><eissn>1469-3178</eissn><abstract>Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis‐associated gallbladder cancer lncRNA (lncRNA‐PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA‐PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA‐PAGBC competitively binds to the tumour suppressive microRNAs miR‐133b and miR‐511. This competitive role of lncRNA‐PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA‐PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.
Synopsis
Long noncoding RNAs play roles in the development and progression of many cancers. In this study the lncRNA PAGBC is identified as promoting tumorigenesis in human gallbladder cancer by competitive binding to the tumour suppressive microRNAs miR‐133b and miR‐511.
LncRNA‐PAGBC is up‐regulated in GBC and increased levels associate with poor prognosis.
LncRNA‐PAGBC promotes tumour growth and metastasis, and activates AKT/mTOR signaling by competitively binding to mirR‐133b and mirR‐511.
LncRNA‐PAGBC interacts with and is stabilized by the polyadenylate binding protein PABPC1.
Graphical Abstract
Long noncoding RNAs play roles in the development and progression of many cancers. In this study the lncRNA PAGBC is identified as promoting tumorigenesis in human gallbladder cancer by competitive binding to the tumour suppressive microRNAs miR‐133b and miR‐511.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28887321</pmid><doi>10.15252/embr.201744147</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0003-4163-2541</orcidid><orcidid>https://orcid.org/0000-0002-1075-1890</orcidid><orcidid>https://orcid.org/0000-0001-6641-6197</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | EMBO reports, 2017-10, Vol.18 (10), p.1837-1853 |
| issn | 1469-221X 1469-3178 1469-3178 |
| language | eng |
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| source | Springer Nature OA Free Journals |
| subjects | AKT protein Binding Cancer Carcinogenesis - genetics Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic ceRNA EMBO03 EMBO36 EMBO37 Functional analysis Gallbladder Gallbladder - physiopathology Gallbladder cancer Gallbladder Neoplasms - genetics Gallbladder Neoplasms - pathology Gene Expression Regulation, Neoplastic Humans lncRNA Metastases Metastasis MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Neoplasm Metastasis PAGBC Pathogenesis Polyadenylation Prognosis Proto-Oncogene Proteins c-akt - metabolism Ribonucleic acid RNA RNA, Long Noncoding - genetics TOR protein TOR Serine-Threonine Kinases - metabolism Tumorigenesis Tumors |
| title | LncRNA‐PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T22%3A03%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_C6C&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=LncRNA%E2%80%90PAGBC%20acts%20as%20a%20microRNA%20sponge%20and%20promotes%20gallbladder%20tumorigenesis&rft.jtitle=EMBO%20reports&rft.au=Wu,%20Xiang%E2%80%90Song&rft.date=2017-10&rft.volume=18&rft.issue=10&rft.spage=1837&rft.epage=1853&rft.pages=1837-1853&rft.issn=1469-221X&rft.eissn=1469-3178&rft_id=info:doi/10.15252/embr.201744147&rft_dat=%3Cproquest_C6C%3E1945033230%3C/proquest_C6C%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1945033230&rft_id=info:pmid/28887321&rfr_iscdi=true |