Lack of interleukin‐6 in the tumor microenvironment augments type‐1 immunity and increases the efficacy of cancer immunotherapy

Conquering immunosuppression in tumor microenvironments is crucial for effective cancer immunotherapy. It is well known that interleukin (IL)‐6, a pleiotropic cytokine, is produced in the tumor‐bearing state. In the present study, we investigated the precise effects of IL‐6 on antitumor immunity and...

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Veröffentlicht in:	Cancer science 2017-10, Vol.108 (10), p.1959-1966
Hauptverfasser:	Ohno, Yosuke, Toyoshima, Yujiro, Yurino, Hideaki, Monma, Norikazu, Xiang, Huihui, Sumida, Kentaro, Kaneumi, Shun, Terada, Satoshi, Hashimoto, Shinichi, Ikeo, Kazuho, Homma, Shigenori, Kawamura, Hideki, Takahashi, Norihiko, Taketomi, Akinobu, Kitamura, Hidemitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Antigens Antitumor activity Apoptosis Cancer immunotherapy CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Cloning Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - immunology Colonic Neoplasms - therapy Colorectal cancer Cytokines Cytotoxic T cells Cytotoxicity Dendritic cells Dendritic Cells - immunology Drug Synergism Effector cells Fibroblasts Flow cytometry Gene expression Gene Expression Regulation, Neoplastic Immune status Immunoglobulins Immunology Immunosuppression Immunotherapy Immunotherapy - methods Interferon Interferon-gamma - metabolism interferon‐γ Interleukin-6 - deficiency Interleukin-6 - genetics interleukin‐6 Kinases Laboratory animals Ligands Lymphocytes Lymphocytes T Major histocompatibility complex Mice Microenvironments Original PD-L1 protein programmed death‐ligand 1 Studies T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Helper-Inducer - immunology Toll-like receptors Tumor Microenvironment - drug effects Tumorigenesis Xenograft Model Antitumor Assays
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