Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson’s disease motor symptoms without neuronal degeneration in adult mice

The type 2 vesicular monoamine transporter (VMAT2), by regulating the storage of monoamines transmitters into synaptic vesicles, has a protective role against their cytoplasmic toxicity. Increasing evidence suggests that impairment of VMAT2 neuroprotection contributes to the pathogenesis of Parkinso...

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Veröffentlicht in:	Scientific reports 2017-09, Vol.7 (1), p.12432-11, Article 12432
Hauptverfasser:	Isingrini, Elsa, Guinaudie, Chloé, C Perret, Léa, Rainer, Quentin, Moquin, Luc, Gratton, Alain, Giros, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	13/44 13/51 42/41 631/378/2587 64/110 692/617/375/1718 Animal models Animals Body weight loss Caudate-putamen Corpus Striatum Cytotoxicity Dependovirus Dopamine Dopaminergic Neurons Drinking Eating Food consumption Gene Deletion Gene Expression Humanities and Social Sciences Injections, Intraventricular Integrases Life Sciences Male Mice Mice, Transgenic Movement disorders multidisciplinary Neostriatum Neurodegeneration Neurodegenerative diseases Neurons and Cognition Neuroprotection Parkinson Disease, Secondary Parkinson's disease Pathogenesis Recombinase Rodents Science Science (multidisciplinary) Substantia Nigra Synaptic Vesicles Toxicity Transgenic mice Vesicular Monoamine Transport Proteins Vesicular monoamine transporter 2 Water consumption Weight Loss
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