Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease

Alzheimer's disease (AD) is a multifactorial disease that is characterized by the formation of intracellular neurofibrillary tangles and extracellular amyloid-β (Aβ) plaque deposits. Increased oxidative stress, metal ion dysregulation, and the formation of toxic Aβ peptide oligomers are all con...

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Veröffentlicht in:	Chemical science (Cambridge) 2017-08, Vol.8 (8), p.5636-5643
Hauptverfasser:	Jones, Michael R, Mathieu, Emilie, Dyrager, Christine, Faissner, Simon, Vaillancourt, Zavier, Korshavn, Kyle J, Lim, Mi Hee, Ramamoorthy, Ayyalusamy, Wee Yong, V, Tsutsui, Shigeki, Stys, Peter K, Storr, Tim
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Chemistry
Online-Zugang:	Volltext
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