SPX-101 Is a Promising and Novel Nebulized ENaC Inhibitor
Optimal hydration of the airway lumen is required for effective mucociliary clearance of inhaled pathogens and particulate matter (1). Because the airway epithelium is relatively permeable to water, the volume and composition of the airway surface liquid (ASL) is determined by active ion transport....
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2017-09, Vol.196 (6), p.671-672 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | Lennox, Alison Myerburg, Mike M |
| description | Optimal hydration of the airway lumen is required for effective mucociliary clearance of inhaled pathogens and particulate matter (1). Because the airway epithelium is relatively permeable to water, the volume and composition of the airway surface liquid (ASL) is determined by active ion transport. In addition to this secretory deficit, the CF airway is hyperabsorptive as a result of dysregulated epithelial sodium channel (ENaC) activity (2-4). Because of these ion transport defects, the airway in CF is exceptionally vulnerable to dehydration, and the luminal contents are abnormally acidic and tenacious. [...]mucus clearance from the CF airway is reduced and causes chronic airway inflammation, obstruction, infection, and ultimately premature respiratory failure. |
| doi_str_mv | 10.1164/rccm.201705-0928ED |
| format | Article |
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| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2017-09, Vol.196 (6), p.671-672 |
| issn | 1073-449X 1535-4970 |
| language | eng |
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| source | MEDLINE; American Thoracic Society (ATS) Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Bacterial Proteins - genetics Clinical trials Cystic fibrosis Gene Expression Regulation, Bacterial Humans Hydration Inflammation Lung diseases Peptides Rodents Sodium |
| title | SPX-101 Is a Promising and Novel Nebulized ENaC Inhibitor |
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