The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling

OBJECTIVE—The role of hemoglobin and myoglobin in the cardiovascular system is well established, yet other globins in this context are poorly characterized. Here, we examined the expression and function of cytoglobin (CYGB) during vascular injury. APPROACH AND RESULTS—We characterized CYGB content i...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2017-10, Vol.37 (10), p.1944-1955
Hauptverfasser:	Jourd’heuil, Frances L, Xu, Haiyan, Reilly, Timothy, McKellar, Keneta, El Alaoui, Chaymae, Steppich, Julia, Liu, Yong Feng, Zhao, Wen, Ginnan, Roman, Conti, David, Lopez-Soler, Reynold, Asif, Arif, Keller, Rebecca K, Schwarz, John J, Thanh Thuy, Le Thi, Kawada, Norifumi, Long, Xiaochun, Singer, Harold A, Jourd’heuil, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Caspase 3 - metabolism Cell Differentiation Cytoglobin Down-Regulation Enzyme Activation Globins - physiology Mice Mice, Knockout Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Neointima - physiopathology Nitric Oxide Synthase Type II - toxicity Oxidation-Reduction Rats Vascular Remodeling - physiology
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