MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro

Hepatic ischaemia/reperfusion (HIR) induces severe damage on hepatocyte cell membrane, which leads to hepatocyte death and the subsequent HIR injury. In this study, we investigated the role and the mechanism of mitsugumin‐53 (MG53), a novel cell membrane repair protein, in protecting the liver again...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2017-10, Vol.21 (10), p.2503-2513
Hauptverfasser:	Yao, Weifeng, Li, Haobo, Han, Xue, Chen, Chaojin, Zhang, Yihan, Tai, Wai Lydia, Xia, Zhengyuan, Hei, Ziqing
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynonenal Animals Apoptosis Apoptosis - drug effects Cell death Cell injury Cell Line Cell Membrane - metabolism dysferlin Dysferlin - genetics Dysferlin - metabolism hepatic ischaemia/reperfusion Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Hypoxia Ischemia Liver Male Membrane proteins Mice mitsugumin‐53 Muscle Proteins - genetics Muscle Proteins - metabolism Muscle Proteins - pharmacology Original Oxidative stress Oxidative Stress - drug effects Protective Agents - metabolism Protective Agents - pharmacology Rats Rats, Sprague-Dawley reactive oxygen species Recombinant Proteins - pharmacology Reperfusion Reperfusion Injury - genetics Reperfusion Injury - metabolism RNA Interference Rodents Superoxide dismutase Transfection Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism Vesicular Transport Proteins - pharmacology
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