IGF-1 Attenuates Hypoxia-Induced Atrophy but Inhibits Myoglobin Expression in C2C12 Skeletal Muscle Myotubes

Chronic hypoxia is associated with muscle wasting and decreased oxidative capacity. By contrast, training under hypoxia may enhance hypertrophy and increase oxidative capacity as well as oxygen transport to the mitochondria, by increasing myoglobin (Mb) expression. The latter may be a feasible strat...

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Veröffentlicht in:	International journal of molecular sciences 2017-09, Vol.18 (9), p.1889
Hauptverfasser:	Peters, Eva L, van der Linde, Sandra M, Vogel, Ilse S P, Haroon, Mohammad, Offringa, Carla, de Wit, Gerard M J, Koolwijk, Pieter, van der Laarse, Willem J, Jaspers, Richard T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy Gene expression Gene Expression Regulation - genetics Humans Hypertrophy Hypoxia Hypoxia - genetics Hypoxia - pathology Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-like growth factors Lipids Mice Mitochondria Mitochondria - genetics Mitochondria - metabolism Muscle contraction Muscle Contraction - drug effects Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - pathology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Atrophy - genetics Muscular Atrophy - pathology Musculoskeletal system Myogenic Regulatory Factors Myoglobin - genetics Myoglobin - metabolism Myoglobins Myotubes Oxygen - metabolism Protein biosynthesis Protein synthesis Rapamycin Rodents Signal Transduction - drug effects Skeletal muscle Succinate Dehydrogenase - genetics Testosterone Congeners - metabolism TOR protein TOR Serine-Threonine Kinases - genetics Transcription
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