Negative Correlation between the Diffusion Coefficient and Transcriptional Activity of the Glucocorticoid Receptor

The glucocorticoid receptor (GR) is a transcription factor, which interacts with DNA and other cofactors to regulate gene transcription. Binding to other partners in the cell nucleus alters the diffusion properties of GR. Raster image correlation spectroscopy (RICS) was applied to quantitatively cha...

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Veröffentlicht in:	International journal of molecular sciences 2017-08, Vol.18 (9), p.1855
Hauptverfasser:	Mikuni, Shintaro, Yamamoto, Johtaro, Horio, Takashi, Kinjo, Masataka
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Cofactors Correlation Deoxyribonucleic acid Diffusion coefficient DNA Gene Expression Regulation Genes Glucocorticoids Glucocorticoids - metabolism Humans Lasers Ligands Microscopy Models, Biological Molecular Imaging Mutant Proteins Nuclei Nuclei (cytology) Phosphorylation Protein Binding Protein Transport Proteins Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Spatial distribution Spectroscopy Spectrum Analysis Transcription factors Transcriptional Activation
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