Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells

Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a genotypically and phenotypically heterogeneous population of neoplastic cells types. High recurrence rate and regional metastases lead to major morbidity and mortality. Recently, many studies have focused on cellular and mo...

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Veröffentlicht in:	International journal of molecular sciences 2017-08, Vol.18 (9), p.1849
Hauptverfasser:	Bourguignon, Lilly Y W, Earle, Christine, Shiina, Marisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Biomarkers CD44 antigen Cell self-renewal Cell surface Chemoresistance Cloning Disease Progression Drug development Drug resistance Drug Resistance, Neoplasm - genetics Epigenesis, Genetic Epigenetics Extracellular Matrix Gene Expression Regulation, Neoplastic Head & neck cancer Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Histone methyltransferase Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Humans Hyaluronan Receptors - metabolism Hyaluronic acid Hyaluronic Acid - chemistry Hyaluronic Acid - metabolism Isoenzymes - metabolism Medical prognosis Metastases Methyltransferases - genetics Methyltransferases - metabolism MicroRNAs - genetics miRNA Molecular modelling Morbidity Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Oct-4 protein Patients Protein Binding Retinal Dehydrogenase - metabolism Review Signal Transduction Squamous cell carcinoma Stem cells Treatment resistance
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