Gene polymorphisms in the PI3K/AKT/mTOR signaling pathway contribute to prostate cancer susceptibility in Chinese men
In this hospital-based case-control study of 413 prostate cancer (PCa) cases and 807 cancer-free controls, we investigated the role of functional single nucleotide polymorphisms (SNPs) of pivotal genes in the PI3K/AKT/mTOR pathway. We genotyped 17 SNPs in , , , , and and found that 4 were associated...
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| Veröffentlicht in: | Oncotarget 2017-09, Vol.8 (37), p.61305-61317 |
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| creator | Liu, Ting Gulinaer, Abulajiang Shi, Xiaoli Wang, Feng An, Hengqing Cui, Wenli Li, Qiaoxin |
| description | In this hospital-based case-control study of 413 prostate cancer (PCa) cases and 807 cancer-free controls, we investigated the role of functional single nucleotide polymorphisms (SNPs) of pivotal genes in the PI3K/AKT/mTOR pathway. We genotyped 17 SNPs in
,
,
,
, and
and found that 4 were associated with PCa susceptibility. Among the variants, the homozygote variant CC genotype of
rs17036508 C>T were associated with higher PCa risk than the wild TT genotypes (adjusted OR = 3.73 (95% CI = 1.75-7.94),
= 0.001). The GT genotype of
rs2295080 G>T was more protective than the TT genotypes (adjusted OR=0.54 (95% CI=0.32-0.91),
0.020). The distributions of
rs1468033 A>G genotypes differed between cases and controls, especially in subgroups defined by age, BMI, smoking status, and ethnicity. The CT/CC genotypes of
rs7250897 C>T were associated with an increased risk of PCa, particularly in subgroups of age >71 and BMI >24 kg/m
. These findings suggest that SNPs in the PI3K/AKT/mTOR pathway may contribute to the risk of PCa in Chinese men. |
| doi_str_mv | 10.18632/oncotarget.18064 |
| format | Article |
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,
,
,
, and
and found that 4 were associated with PCa susceptibility. Among the variants, the homozygote variant CC genotype of
rs17036508 C>T were associated with higher PCa risk than the wild TT genotypes (adjusted OR = 3.73 (95% CI = 1.75-7.94),
= 0.001). The GT genotype of
rs2295080 G>T was more protective than the TT genotypes (adjusted OR=0.54 (95% CI=0.32-0.91),
0.020). The distributions of
rs1468033 A>G genotypes differed between cases and controls, especially in subgroups defined by age, BMI, smoking status, and ethnicity. The CT/CC genotypes of
rs7250897 C>T were associated with an increased risk of PCa, particularly in subgroups of age >71 and BMI >24 kg/m
. These findings suggest that SNPs in the PI3K/AKT/mTOR pathway may contribute to the risk of PCa in Chinese men.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.18064</identifier><identifier>PMID: 28977864</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Research Paper</subject><ispartof>Oncotarget, 2017-09, Vol.8 (37), p.61305-61317</ispartof><rights>Copyright: © 2017 Liu et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-943b30515a1fb98aa48a3a79d0da6bb501d0a00e2992c2c8b551ae85f5a472923</citedby><cites>FETCH-LOGICAL-c356t-943b30515a1fb98aa48a3a79d0da6bb501d0a00e2992c2c8b551ae85f5a472923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617424/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617424/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28977864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Ting</creatorcontrib><creatorcontrib>Gulinaer, Abulajiang</creatorcontrib><creatorcontrib>Shi, Xiaoli</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>An, Hengqing</creatorcontrib><creatorcontrib>Cui, Wenli</creatorcontrib><creatorcontrib>Li, Qiaoxin</creatorcontrib><title>Gene polymorphisms in the PI3K/AKT/mTOR signaling pathway contribute to prostate cancer susceptibility in Chinese men</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>In this hospital-based case-control study of 413 prostate cancer (PCa) cases and 807 cancer-free controls, we investigated the role of functional single nucleotide polymorphisms (SNPs) of pivotal genes in the PI3K/AKT/mTOR pathway. We genotyped 17 SNPs in
,
,
,
, and
and found that 4 were associated with PCa susceptibility. Among the variants, the homozygote variant CC genotype of
rs17036508 C>T were associated with higher PCa risk than the wild TT genotypes (adjusted OR = 3.73 (95% CI = 1.75-7.94),
= 0.001). The GT genotype of
rs2295080 G>T was more protective than the TT genotypes (adjusted OR=0.54 (95% CI=0.32-0.91),
0.020). The distributions of
rs1468033 A>G genotypes differed between cases and controls, especially in subgroups defined by age, BMI, smoking status, and ethnicity. The CT/CC genotypes of
rs7250897 C>T were associated with an increased risk of PCa, particularly in subgroups of age >71 and BMI >24 kg/m
. These findings suggest that SNPs in the PI3K/AKT/mTOR pathway may contribute to the risk of PCa in Chinese men.</description><subject>Research Paper</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVUUtv1DAQthCIVqU_gAvykcuyfibxBalaQalaqQgtZ2vind0YJXawHdD-e9wHpcxlRjPffPP4CHnL2QfeNVKsY3CxQDpgqQnWqBfklBtlVkJr-fJZfELOc_7BqmnVdsK8JieiM23bNeqULJcYkM5xPE4xzYPPU6Y-0DIg_Xolr9cX19v1tL39RrM_BBh9ONAZyvAbjtTFUJLvl4K0RDqnmAvU2EFwmGhessO5-N6PvhzvODeDD5iRThjekFd7GDOeP_oz8v3zp-3my-rm9vJqc3GzclI3ZWWU7CXTXAPf96YDUB1IaM2O7aDpe834jgFjKIwRTriu15oDdnqvQbXCCHlGPj7wzks_4c5h3RhGOyc_QTraCN7-Xwl-sIf4y-qGt0qoSvD-kSDFnwvmYidf7xpHCBiXbOuT2zuobCqUP0Bd_UROuH8aw5m9V8z-U8zeK1Z73j3f76njrz7yDwDdlzE</recordid><startdate>20170922</startdate><enddate>20170922</enddate><creator>Liu, Ting</creator><creator>Gulinaer, Abulajiang</creator><creator>Shi, Xiaoli</creator><creator>Wang, Feng</creator><creator>An, Hengqing</creator><creator>Cui, Wenli</creator><creator>Li, Qiaoxin</creator><general>Impact Journals LLC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170922</creationdate><title>Gene polymorphisms in the PI3K/AKT/mTOR signaling pathway contribute to prostate cancer susceptibility in Chinese men</title><author>Liu, Ting ; Gulinaer, Abulajiang ; Shi, Xiaoli ; Wang, Feng ; An, Hengqing ; Cui, Wenli ; Li, Qiaoxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-943b30515a1fb98aa48a3a79d0da6bb501d0a00e2992c2c8b551ae85f5a472923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Research Paper</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ting</creatorcontrib><creatorcontrib>Gulinaer, Abulajiang</creatorcontrib><creatorcontrib>Shi, Xiaoli</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>An, Hengqing</creatorcontrib><creatorcontrib>Cui, Wenli</creatorcontrib><creatorcontrib>Li, Qiaoxin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ting</au><au>Gulinaer, Abulajiang</au><au>Shi, Xiaoli</au><au>Wang, Feng</au><au>An, Hengqing</au><au>Cui, Wenli</au><au>Li, Qiaoxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene polymorphisms in the PI3K/AKT/mTOR signaling pathway contribute to prostate cancer susceptibility in Chinese men</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-09-22</date><risdate>2017</risdate><volume>8</volume><issue>37</issue><spage>61305</spage><epage>61317</epage><pages>61305-61317</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>In this hospital-based case-control study of 413 prostate cancer (PCa) cases and 807 cancer-free controls, we investigated the role of functional single nucleotide polymorphisms (SNPs) of pivotal genes in the PI3K/AKT/mTOR pathway. We genotyped 17 SNPs in
,
,
,
, and
and found that 4 were associated with PCa susceptibility. Among the variants, the homozygote variant CC genotype of
rs17036508 C>T were associated with higher PCa risk than the wild TT genotypes (adjusted OR = 3.73 (95% CI = 1.75-7.94),
= 0.001). The GT genotype of
rs2295080 G>T was more protective than the TT genotypes (adjusted OR=0.54 (95% CI=0.32-0.91),
0.020). The distributions of
rs1468033 A>G genotypes differed between cases and controls, especially in subgroups defined by age, BMI, smoking status, and ethnicity. The CT/CC genotypes of
rs7250897 C>T were associated with an increased risk of PCa, particularly in subgroups of age >71 and BMI >24 kg/m
. These findings suggest that SNPs in the PI3K/AKT/mTOR pathway may contribute to the risk of PCa in Chinese men.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>28977864</pmid><doi>10.18632/oncotarget.18064</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Research Paper |
| title | Gene polymorphisms in the PI3K/AKT/mTOR signaling pathway contribute to prostate cancer susceptibility in Chinese men |
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