Epigenome‐wide Association of DNA Methylation in Whole Blood With Bone Mineral Density

ABSTRACT Genetic and environmental determinants of skeletal phenotypes such as bone mineral density (BMD) may converge through the epigenome, providing a tool to better understand osteoporosis pathophysiology. Because the epigenetics of BMD have been largely unexplored in humans, we performed an epi...

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Veröffentlicht in:	Journal of bone and mineral research 2017-08, Vol.32 (8), p.1644-1650
Hauptverfasser:	Morris, John A, Tsai, Pei‐Chien, Joehanes, Roby, Zheng, Jie, Trajanoska, Katerina, Soerensen, Mette, Forgetta, Vincenzo, Castillo‐Fernandez, Juan Edgar, Frost, Morten, Spector, Tim D, Christensen, Kaare, Christiansen, Lene, Rivadeneira, Fernando, Tobias, Jonathan H, Evans, David M, Kiel, Douglas P, Hsu, Yi‐Hsiang, Richards, J Brent, Bell, Jordana T
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Blood Cells - metabolism Bone Density BONE MINERAL DENSITY CpG Islands Cytosine Deoxyribonucleic acid DNA DNA METHYLATION DNA probes Dual energy X-ray absorptiometry Epigenesis, Genetic EPIGENETICS EPIGENOME‐WIDE ASSOCIATION STUDY (EWAS) Female Females Femur Femur Neck - metabolism GENETIC EPIDEMIOLOGY Genome-Wide Association Study Genomes Guanine Humans Male Original Osteoporosis Smoking Spine (lumbar) Twins
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