Endocytosis and lysosomal degradation of GluA2/3 AMPARs in response to oxygen/glucose deprivation in hippocampal but not cortical neurons

Global cerebral ischemia results in oxygen and glucose deprivation (OGD) and consequent delayed cell death of vulnerable neurons, with hippocampal CA1 neurons more vulnerable than cortical neurons. Most AMPA receptors (AMPARs) are heteromeric complexes of subunits GluA1/GluA2 or GluA2/GluA3, and the...

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Veröffentlicht in:	Scientific reports 2017-09, Vol.7 (1), p.12318-12, Article 12318
Hauptverfasser:	Koszegi, Zsombor, Fiuza, Maria, Hanley, Jonathan G.
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/1 14/19 631/378/1689/534 631/80/313/1624 82 82/80 96 Adaptor Protein Complex 2 - metabolism Animals Apoptosis Brain Ischemia - pathology CA1 Region, Hippocampal - cytology CA1 Region, Hippocampal - pathology Calcium influx Calcium permeability Carrier Proteins - metabolism Cell death Cell surface Cells, Cultured Cytoskeletal Proteins Endocytosis Gene expression Glucose Glucose - metabolism Hippocampus Humanities and Social Sciences Hypotheses Ischemia Lysosomes Lysosomes - metabolism multidisciplinary Neurons - pathology Nuclear Proteins - metabolism Oxygen Oxygen - metabolism Plasma Primary Cell Culture Proteolysis Rats Rats, Wistar Receptors, AMPA - metabolism Science Science (multidisciplinary) Subunit structure α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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