The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks
The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by metazoans. In this review, we highlight recent progress in understanding the overlapping versus specific roles of EGLN enzymes an...
Gespeichert in:
| Veröffentlicht in: | Molecular cell 2017-06, Vol.66 (6), p.772-779 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 779 |
|---|---|
| container_issue | 6 |
| container_start_page | 772 |
| container_title | Molecular cell |
| container_volume | 66 |
| creator | Ivan, Mircea Kaelin, William G. |
| description | The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by metazoans. In this review, we highlight recent progress in understanding the overlapping versus specific roles of EGLN enzymes and HIF isoforms and discuss how feedback loops based on recently identified noncoding RNAs introduce additional layers of complexity to the hypoxic response. Based on novel interactions identified upstream and downstream of EGLNs, an integrated network connecting oxygen-sensing functions to metabolic and signaling pathways is gradually emerging with broad therapeutic implications.
This review from Mircea and Kealin provides a historical perspective on prolyl hydroxylases and their HIF targets, and delves into the more complex role that feedback loops and noncoding RNAs play in sensing and regulating response to hypoxia. |
| doi_str_mv | 10.1016/j.molcel.2017.06.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5613951</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1097276517304045</els_id><sourcerecordid>1910797929</sourcerecordid><originalsourceid>FETCH-LOGICAL-e213t-9544f5c24258802007e3fcc0a9a899f93031686a67508b4029fe633935dada583</originalsourceid><addsrcrecordid>eNpVkdFKwzAUhoMoTqdv4EUvvWk9SZq0ERREnA6mu9i8Dll6umW26Wxawbe3w4F4dQ4c-A7__xFyRSGhQOXNNqmbymKVMKBZAjIBYEfkjILK4pTK9Piws0yKETkPYQtAU5GrUzJiuWRMMHZG7pYbjJ6eZ2_xy3QSzVm8QB-cX0eL79BhfRu99lXndhVGU7_ruxAZX0QTxGJl7Ee4ICelqQJeHuaYvE-elo8v8Wz-PH18mMXIKO9iJdK0FJalTOQ5MIAMeWktGGVypUrFgVOZSyMzAfkqBaZKlJwrLgpTGJHzMbn_5e76VY2FRd-1ptK71tWm_daNcfr_xbuNXjdfWkjKlaAD4PoAaJvPHkOnaxeG8irjsemDpopCpjLF1N8vHAJ9OWx1sA69xcK1aDtdNE5T0HsHeqt_Hei9Aw1SDw74D6ljeRM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1910797929</pqid></control><display><type>article</type><title>The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks</title><source>Cell Press Free Archives</source><source>ScienceDirect Journals (5 years ago - present)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Ivan, Mircea ; Kaelin, William G.</creator><creatorcontrib>Ivan, Mircea ; Kaelin, William G.</creatorcontrib><description>The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by metazoans. In this review, we highlight recent progress in understanding the overlapping versus specific roles of EGLN enzymes and HIF isoforms and discuss how feedback loops based on recently identified noncoding RNAs introduce additional layers of complexity to the hypoxic response. Based on novel interactions identified upstream and downstream of EGLNs, an integrated network connecting oxygen-sensing functions to metabolic and signaling pathways is gradually emerging with broad therapeutic implications.
This review from Mircea and Kealin provides a historical perspective on prolyl hydroxylases and their HIF targets, and delves into the more complex role that feedback loops and noncoding RNAs play in sensing and regulating response to hypoxia.</description><identifier>ISSN: 1097-2765</identifier><identifier>EISSN: 1097-4164</identifier><identifier>DOI: 10.1016/j.molcel.2017.06.002</identifier><identifier>PMID: 28622522</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>EGLN ; HIF1α ; HIF2α ; hypoxia ; lncRNA ; metabolism ; miRNA ; noncoding RNA ; oxygen ; PHD</subject><ispartof>Molecular cell, 2017-06, Vol.66 (6), p.772-779</ispartof><rights>2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.molcel.2017.06.002$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids></links><search><creatorcontrib>Ivan, Mircea</creatorcontrib><creatorcontrib>Kaelin, William G.</creatorcontrib><title>The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks</title><title>Molecular cell</title><description>The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by metazoans. In this review, we highlight recent progress in understanding the overlapping versus specific roles of EGLN enzymes and HIF isoforms and discuss how feedback loops based on recently identified noncoding RNAs introduce additional layers of complexity to the hypoxic response. Based on novel interactions identified upstream and downstream of EGLNs, an integrated network connecting oxygen-sensing functions to metabolic and signaling pathways is gradually emerging with broad therapeutic implications.
This review from Mircea and Kealin provides a historical perspective on prolyl hydroxylases and their HIF targets, and delves into the more complex role that feedback loops and noncoding RNAs play in sensing and regulating response to hypoxia.</description><subject>EGLN</subject><subject>HIF1α</subject><subject>HIF2α</subject><subject>hypoxia</subject><subject>lncRNA</subject><subject>metabolism</subject><subject>miRNA</subject><subject>noncoding RNA</subject><subject>oxygen</subject><subject>PHD</subject><issn>1097-2765</issn><issn>1097-4164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkdFKwzAUhoMoTqdv4EUvvWk9SZq0ERREnA6mu9i8Dll6umW26Wxawbe3w4F4dQ4c-A7__xFyRSGhQOXNNqmbymKVMKBZAjIBYEfkjILK4pTK9Piws0yKETkPYQtAU5GrUzJiuWRMMHZG7pYbjJ6eZ2_xy3QSzVm8QB-cX0eL79BhfRu99lXndhVGU7_ruxAZX0QTxGJl7Ee4ICelqQJeHuaYvE-elo8v8Wz-PH18mMXIKO9iJdK0FJalTOQ5MIAMeWktGGVypUrFgVOZSyMzAfkqBaZKlJwrLgpTGJHzMbn_5e76VY2FRd-1ptK71tWm_daNcfr_xbuNXjdfWkjKlaAD4PoAaJvPHkOnaxeG8irjsemDpopCpjLF1N8vHAJ9OWx1sA69xcK1aDtdNE5T0HsHeqt_Hei9Aw1SDw74D6ljeRM</recordid><startdate>20170615</startdate><enddate>20170615</enddate><creator>Ivan, Mircea</creator><creator>Kaelin, William G.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170615</creationdate><title>The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks</title><author>Ivan, Mircea ; Kaelin, William G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e213t-9544f5c24258802007e3fcc0a9a899f93031686a67508b4029fe633935dada583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>EGLN</topic><topic>HIF1α</topic><topic>HIF2α</topic><topic>hypoxia</topic><topic>lncRNA</topic><topic>metabolism</topic><topic>miRNA</topic><topic>noncoding RNA</topic><topic>oxygen</topic><topic>PHD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ivan, Mircea</creatorcontrib><creatorcontrib>Kaelin, William G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ivan, Mircea</au><au>Kaelin, William G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks</atitle><jtitle>Molecular cell</jtitle><date>2017-06-15</date><risdate>2017</risdate><volume>66</volume><issue>6</issue><spage>772</spage><epage>779</epage><pages>772-779</pages><issn>1097-2765</issn><eissn>1097-4164</eissn><abstract>The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by metazoans. In this review, we highlight recent progress in understanding the overlapping versus specific roles of EGLN enzymes and HIF isoforms and discuss how feedback loops based on recently identified noncoding RNAs introduce additional layers of complexity to the hypoxic response. Based on novel interactions identified upstream and downstream of EGLNs, an integrated network connecting oxygen-sensing functions to metabolic and signaling pathways is gradually emerging with broad therapeutic implications.
This review from Mircea and Kealin provides a historical perspective on prolyl hydroxylases and their HIF targets, and delves into the more complex role that feedback loops and noncoding RNAs play in sensing and regulating response to hypoxia.</abstract><pub>Elsevier Inc</pub><pmid>28622522</pmid><doi>10.1016/j.molcel.2017.06.002</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1097-2765 |
| ispartof | Molecular cell, 2017-06, Vol.66 (6), p.772-779 |
| issn | 1097-2765 1097-4164 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5613951 |
| source | Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | EGLN HIF1α HIF2α hypoxia lncRNA metabolism miRNA noncoding RNA oxygen PHD |
| title | The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T02%3A08%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20EGLN-HIF%20O2-Sensing%20System:%20Multiple%20Inputs%20and%20Feedbacks&rft.jtitle=Molecular%20cell&rft.au=Ivan,%20Mircea&rft.date=2017-06-15&rft.volume=66&rft.issue=6&rft.spage=772&rft.epage=779&rft.pages=772-779&rft.issn=1097-2765&rft.eissn=1097-4164&rft_id=info:doi/10.1016/j.molcel.2017.06.002&rft_dat=%3Cproquest_pubme%3E1910797929%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1910797929&rft_id=info:pmid/28622522&rft_els_id=S1097276517304045&rfr_iscdi=true |