Chronic Auditory Toxicity in Late Preterm and Term Infants With Significant Hyperbilirubinemia

Significant hyperbilirubinemia (SHB) may cause chronic auditory toxicity (auditory neuropathy spectrum disorder and/or sensorineural hearing loss); however, total serum bilirubin (TSB) does not discriminate neonates at risk for auditory toxicity. Our objective was to compare TSB, bilirubin albumin m...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pediatrics (Evanston) 2017-10, Vol.140 (4), p.1
Hauptverfasser: Amin, Sanjiv B, Saluja, Satish, Saili, Arvind, Orlando, Mark, Wang, Hongyue, Laroia, Nirupama, Agarwal, Asha
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 4
container_start_page 1
container_title Pediatrics (Evanston)
container_volume 140
creator Amin, Sanjiv B
Saluja, Satish
Saili, Arvind
Orlando, Mark
Wang, Hongyue
Laroia, Nirupama
Agarwal, Asha
description Significant hyperbilirubinemia (SHB) may cause chronic auditory toxicity (auditory neuropathy spectrum disorder and/or sensorineural hearing loss); however, total serum bilirubin (TSB) does not discriminate neonates at risk for auditory toxicity. Our objective was to compare TSB, bilirubin albumin molar ratio (BAMR), and unbound bilirubin (UB) for their association with chronic auditory toxicity in neonates with SHB (TSB ≥20 mg/dL or TSB that met criteria for exchange transfusion). Infants ≥34 weeks' gestational age (GA) with SHB during the first 2 postnatal weeks were eligible for a prospective longitudinal study in India. Comprehensive auditory evaluations were performed at 2 to 3 months of age by using auditory brainstem response, tympanometry, and an otoacoustic emission test and at 9 to 12 months of age by using audiometry. The evaluations were performed by an audiologist unaware of the degree of jaundice. A total of 93 out of 100 infants (mean GA of 37.4 weeks; 55 boys, 38 girls) who were enrolled with SHB were evaluated for auditory toxicity. Of those, 12 infants (13%) had auditory toxicity. On regression analysis controlling for covariates, peak UB (but not peak TSB or peak BAMR), was associated with auditory toxicity (odds ratio 2.41; 95% confidence interval: 1.43-4.07; .001). There was significant difference in the area under the receiver operating characteristic curves between UB (0.866), TSB (0.775), and BAMR (0.724) for auditory toxicity ( = .03) after controlling for covariates. Unconjugated hyperbilirubinemia indexed by UB (but not TSB or BAMR) is associated with chronic auditory toxicity in infants ≥34 weeks' GA with SHB.
doi_str_mv 10.1542/peds.2016-4009
format Article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5613832</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A527591216</galeid><sourcerecordid>A527591216</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-7e6948c0c8c3828288808212d750388ad2262b2e10743dd9334720466b718a653</originalsourceid><addsrcrecordid>eNpdkc-LEzEUx4Mobnf16lECXrxMze_JXIRS1F0orGDFmyGTeW2zzCQ1ycj2v3eG7i4qOSS8fPJ9eXwQekPJkkrBPhyhy0tGqKoEIc0ztKCk0ZVgtXyOFoRwOtflBbrM-Y4QImTNXqILphspdM0X6Of6kGLwDq_GzpeYTngb773z5YR9wBtbAH9NUCAN2IYOb-fDTdjZUDL-4csBf_P74HfeTRV8fTpCan3v09j6AIO3r9CLne0zvH7Yr9D3z5-26-tqc_vlZr3aVE5IVaoaVCO0I047rtm0tCaaUdbVknCtbceYYi0DSmrBu67hXNSMCKXammqrJL9CH8-5x7EdoHMQSrK9OSY_2HQy0Xrz703wB7OPv41UlGvOpoD3DwEp_hohFzP47KDvbYA4ZkMbIQSXrJl7vfsPvYtjCtN4E6UU0UITNVHVmdrbHowPLoYC98XFvoc9mGn69a1ZyUlUQxmd-eWZdynmnGD39HlKzKzazKrNrNrMqqcHb_8e-Ql_dMv_ANX0ozw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1966084806</pqid></control><display><type>article</type><title>Chronic Auditory Toxicity in Late Preterm and Term Infants With Significant Hyperbilirubinemia</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Amin, Sanjiv B ; Saluja, Satish ; Saili, Arvind ; Orlando, Mark ; Wang, Hongyue ; Laroia, Nirupama ; Agarwal, Asha</creator><creatorcontrib>Amin, Sanjiv B ; Saluja, Satish ; Saili, Arvind ; Orlando, Mark ; Wang, Hongyue ; Laroia, Nirupama ; Agarwal, Asha</creatorcontrib><description>Significant hyperbilirubinemia (SHB) may cause chronic auditory toxicity (auditory neuropathy spectrum disorder and/or sensorineural hearing loss); however, total serum bilirubin (TSB) does not discriminate neonates at risk for auditory toxicity. Our objective was to compare TSB, bilirubin albumin molar ratio (BAMR), and unbound bilirubin (UB) for their association with chronic auditory toxicity in neonates with SHB (TSB ≥20 mg/dL or TSB that met criteria for exchange transfusion). Infants ≥34 weeks' gestational age (GA) with SHB during the first 2 postnatal weeks were eligible for a prospective longitudinal study in India. Comprehensive auditory evaluations were performed at 2 to 3 months of age by using auditory brainstem response, tympanometry, and an otoacoustic emission test and at 9 to 12 months of age by using audiometry. The evaluations were performed by an audiologist unaware of the degree of jaundice. A total of 93 out of 100 infants (mean GA of 37.4 weeks; 55 boys, 38 girls) who were enrolled with SHB were evaluated for auditory toxicity. Of those, 12 infants (13%) had auditory toxicity. On regression analysis controlling for covariates, peak UB (but not peak TSB or peak BAMR), was associated with auditory toxicity (odds ratio 2.41; 95% confidence interval: 1.43-4.07; .001). There was significant difference in the area under the receiver operating characteristic curves between UB (0.866), TSB (0.775), and BAMR (0.724) for auditory toxicity ( = .03) after controlling for covariates. Unconjugated hyperbilirubinemia indexed by UB (but not TSB or BAMR) is associated with chronic auditory toxicity in infants ≥34 weeks' GA with SHB.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2016-4009</identifier><identifier>PMID: 28954873</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Age ; Audiometry ; Babies ; Bilirubin ; Bilirubin - blood ; Biomarkers - blood ; Blood diseases ; Brain stem ; Chronic Disease ; Complications and side effects ; Ears &amp; hearing ; Emission analysis ; Female ; Gestational age ; Health aspects ; Hearing loss ; Hearing Loss, Central - blood ; Hearing Loss, Central - diagnosis ; Hearing Loss, Central - epidemiology ; Hearing Loss, Central - etiology ; Hearing Loss, Sensorineural - blood ; Hearing Loss, Sensorineural - diagnosis ; Hearing Loss, Sensorineural - epidemiology ; Hearing Loss, Sensorineural - etiology ; Humans ; Hyperbilirubinemia ; Hyperbilirubinemia, Neonatal - blood ; Hyperbilirubinemia, Neonatal - complications ; Hyperbilirubinemia, Neonatal - diagnosis ; Incidence ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - blood ; Infant, Premature, Diseases - diagnosis ; Infant, Premature, Diseases - epidemiology ; Infant, Premature, Diseases - etiology ; Infants ; Infants (Premature) ; Jaundice ; Longitudinal Studies ; Male ; Neonates ; Neuropathy ; Pediatrics ; Premature infants ; Prospective Studies ; Regression analysis ; Risk Assessment ; Risk Factors ; ROC Curve ; Serum Albumin - metabolism ; Toxicity ; Transfusion</subject><ispartof>Pediatrics (Evanston), 2017-10, Vol.140 (4), p.1</ispartof><rights>Copyright © 2017 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics Oct 2017</rights><rights>Copyright © 2017 by the American Academy of Pediatrics 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-7e6948c0c8c3828288808212d750388ad2262b2e10743dd9334720466b718a653</citedby><cites>FETCH-LOGICAL-c456t-7e6948c0c8c3828288808212d750388ad2262b2e10743dd9334720466b718a653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28954873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amin, Sanjiv B</creatorcontrib><creatorcontrib>Saluja, Satish</creatorcontrib><creatorcontrib>Saili, Arvind</creatorcontrib><creatorcontrib>Orlando, Mark</creatorcontrib><creatorcontrib>Wang, Hongyue</creatorcontrib><creatorcontrib>Laroia, Nirupama</creatorcontrib><creatorcontrib>Agarwal, Asha</creatorcontrib><title>Chronic Auditory Toxicity in Late Preterm and Term Infants With Significant Hyperbilirubinemia</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Significant hyperbilirubinemia (SHB) may cause chronic auditory toxicity (auditory neuropathy spectrum disorder and/or sensorineural hearing loss); however, total serum bilirubin (TSB) does not discriminate neonates at risk for auditory toxicity. Our objective was to compare TSB, bilirubin albumin molar ratio (BAMR), and unbound bilirubin (UB) for their association with chronic auditory toxicity in neonates with SHB (TSB ≥20 mg/dL or TSB that met criteria for exchange transfusion). Infants ≥34 weeks' gestational age (GA) with SHB during the first 2 postnatal weeks were eligible for a prospective longitudinal study in India. Comprehensive auditory evaluations were performed at 2 to 3 months of age by using auditory brainstem response, tympanometry, and an otoacoustic emission test and at 9 to 12 months of age by using audiometry. The evaluations were performed by an audiologist unaware of the degree of jaundice. A total of 93 out of 100 infants (mean GA of 37.4 weeks; 55 boys, 38 girls) who were enrolled with SHB were evaluated for auditory toxicity. Of those, 12 infants (13%) had auditory toxicity. On regression analysis controlling for covariates, peak UB (but not peak TSB or peak BAMR), was associated with auditory toxicity (odds ratio 2.41; 95% confidence interval: 1.43-4.07; .001). There was significant difference in the area under the receiver operating characteristic curves between UB (0.866), TSB (0.775), and BAMR (0.724) for auditory toxicity ( = .03) after controlling for covariates. Unconjugated hyperbilirubinemia indexed by UB (but not TSB or BAMR) is associated with chronic auditory toxicity in infants ≥34 weeks' GA with SHB.</description><subject>Age</subject><subject>Audiometry</subject><subject>Babies</subject><subject>Bilirubin</subject><subject>Bilirubin - blood</subject><subject>Biomarkers - blood</subject><subject>Blood diseases</subject><subject>Brain stem</subject><subject>Chronic Disease</subject><subject>Complications and side effects</subject><subject>Ears &amp; hearing</subject><subject>Emission analysis</subject><subject>Female</subject><subject>Gestational age</subject><subject>Health aspects</subject><subject>Hearing loss</subject><subject>Hearing Loss, Central - blood</subject><subject>Hearing Loss, Central - diagnosis</subject><subject>Hearing Loss, Central - epidemiology</subject><subject>Hearing Loss, Central - etiology</subject><subject>Hearing Loss, Sensorineural - blood</subject><subject>Hearing Loss, Sensorineural - diagnosis</subject><subject>Hearing Loss, Sensorineural - epidemiology</subject><subject>Hearing Loss, Sensorineural - etiology</subject><subject>Humans</subject><subject>Hyperbilirubinemia</subject><subject>Hyperbilirubinemia, Neonatal - blood</subject><subject>Hyperbilirubinemia, Neonatal - complications</subject><subject>Hyperbilirubinemia, Neonatal - diagnosis</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - blood</subject><subject>Infant, Premature, Diseases - diagnosis</subject><subject>Infant, Premature, Diseases - epidemiology</subject><subject>Infant, Premature, Diseases - etiology</subject><subject>Infants</subject><subject>Infants (Premature)</subject><subject>Jaundice</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Neonates</subject><subject>Neuropathy</subject><subject>Pediatrics</subject><subject>Premature infants</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Serum Albumin - metabolism</subject><subject>Toxicity</subject><subject>Transfusion</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc-LEzEUx4Mobnf16lECXrxMze_JXIRS1F0orGDFmyGTeW2zzCQ1ycj2v3eG7i4qOSS8fPJ9eXwQekPJkkrBPhyhy0tGqKoEIc0ztKCk0ZVgtXyOFoRwOtflBbrM-Y4QImTNXqILphspdM0X6Of6kGLwDq_GzpeYTngb773z5YR9wBtbAH9NUCAN2IYOb-fDTdjZUDL-4csBf_P74HfeTRV8fTpCan3v09j6AIO3r9CLne0zvH7Yr9D3z5-26-tqc_vlZr3aVE5IVaoaVCO0I047rtm0tCaaUdbVknCtbceYYi0DSmrBu67hXNSMCKXammqrJL9CH8-5x7EdoHMQSrK9OSY_2HQy0Xrz703wB7OPv41UlGvOpoD3DwEp_hohFzP47KDvbYA4ZkMbIQSXrJl7vfsPvYtjCtN4E6UU0UITNVHVmdrbHowPLoYC98XFvoc9mGn69a1ZyUlUQxmd-eWZdynmnGD39HlKzKzazKrNrNrMqqcHb_8e-Ql_dMv_ANX0ozw</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Amin, Sanjiv B</creator><creator>Saluja, Satish</creator><creator>Saili, Arvind</creator><creator>Orlando, Mark</creator><creator>Wang, Hongyue</creator><creator>Laroia, Nirupama</creator><creator>Agarwal, Asha</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201710</creationdate><title>Chronic Auditory Toxicity in Late Preterm and Term Infants With Significant Hyperbilirubinemia</title><author>Amin, Sanjiv B ; Saluja, Satish ; Saili, Arvind ; Orlando, Mark ; Wang, Hongyue ; Laroia, Nirupama ; Agarwal, Asha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-7e6948c0c8c3828288808212d750388ad2262b2e10743dd9334720466b718a653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Audiometry</topic><topic>Babies</topic><topic>Bilirubin</topic><topic>Bilirubin - blood</topic><topic>Biomarkers - blood</topic><topic>Blood diseases</topic><topic>Brain stem</topic><topic>Chronic Disease</topic><topic>Complications and side effects</topic><topic>Ears &amp; hearing</topic><topic>Emission analysis</topic><topic>Female</topic><topic>Gestational age</topic><topic>Health aspects</topic><topic>Hearing loss</topic><topic>Hearing Loss, Central - blood</topic><topic>Hearing Loss, Central - diagnosis</topic><topic>Hearing Loss, Central - epidemiology</topic><topic>Hearing Loss, Central - etiology</topic><topic>Hearing Loss, Sensorineural - blood</topic><topic>Hearing Loss, Sensorineural - diagnosis</topic><topic>Hearing Loss, Sensorineural - epidemiology</topic><topic>Hearing Loss, Sensorineural - etiology</topic><topic>Humans</topic><topic>Hyperbilirubinemia</topic><topic>Hyperbilirubinemia, Neonatal - blood</topic><topic>Hyperbilirubinemia, Neonatal - complications</topic><topic>Hyperbilirubinemia, Neonatal - diagnosis</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - blood</topic><topic>Infant, Premature, Diseases - diagnosis</topic><topic>Infant, Premature, Diseases - epidemiology</topic><topic>Infant, Premature, Diseases - etiology</topic><topic>Infants</topic><topic>Infants (Premature)</topic><topic>Jaundice</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Neonates</topic><topic>Neuropathy</topic><topic>Pediatrics</topic><topic>Premature infants</topic><topic>Prospective Studies</topic><topic>Regression analysis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Serum Albumin - metabolism</topic><topic>Toxicity</topic><topic>Transfusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amin, Sanjiv B</creatorcontrib><creatorcontrib>Saluja, Satish</creatorcontrib><creatorcontrib>Saili, Arvind</creatorcontrib><creatorcontrib>Orlando, Mark</creatorcontrib><creatorcontrib>Wang, Hongyue</creatorcontrib><creatorcontrib>Laroia, Nirupama</creatorcontrib><creatorcontrib>Agarwal, Asha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amin, Sanjiv B</au><au>Saluja, Satish</au><au>Saili, Arvind</au><au>Orlando, Mark</au><au>Wang, Hongyue</au><au>Laroia, Nirupama</au><au>Agarwal, Asha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic Auditory Toxicity in Late Preterm and Term Infants With Significant Hyperbilirubinemia</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2017-10</date><risdate>2017</risdate><volume>140</volume><issue>4</issue><spage>1</spage><pages>1-</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>Significant hyperbilirubinemia (SHB) may cause chronic auditory toxicity (auditory neuropathy spectrum disorder and/or sensorineural hearing loss); however, total serum bilirubin (TSB) does not discriminate neonates at risk for auditory toxicity. Our objective was to compare TSB, bilirubin albumin molar ratio (BAMR), and unbound bilirubin (UB) for their association with chronic auditory toxicity in neonates with SHB (TSB ≥20 mg/dL or TSB that met criteria for exchange transfusion). Infants ≥34 weeks' gestational age (GA) with SHB during the first 2 postnatal weeks were eligible for a prospective longitudinal study in India. Comprehensive auditory evaluations were performed at 2 to 3 months of age by using auditory brainstem response, tympanometry, and an otoacoustic emission test and at 9 to 12 months of age by using audiometry. The evaluations were performed by an audiologist unaware of the degree of jaundice. A total of 93 out of 100 infants (mean GA of 37.4 weeks; 55 boys, 38 girls) who were enrolled with SHB were evaluated for auditory toxicity. Of those, 12 infants (13%) had auditory toxicity. On regression analysis controlling for covariates, peak UB (but not peak TSB or peak BAMR), was associated with auditory toxicity (odds ratio 2.41; 95% confidence interval: 1.43-4.07; .001). There was significant difference in the area under the receiver operating characteristic curves between UB (0.866), TSB (0.775), and BAMR (0.724) for auditory toxicity ( = .03) after controlling for covariates. Unconjugated hyperbilirubinemia indexed by UB (but not TSB or BAMR) is associated with chronic auditory toxicity in infants ≥34 weeks' GA with SHB.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>28954873</pmid><doi>10.1542/peds.2016-4009</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0031-4005
ispartof Pediatrics (Evanston), 2017-10, Vol.140 (4), p.1
issn 0031-4005
1098-4275
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5613832
source MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Age
Audiometry
Babies
Bilirubin
Bilirubin - blood
Biomarkers - blood
Blood diseases
Brain stem
Chronic Disease
Complications and side effects
Ears & hearing
Emission analysis
Female
Gestational age
Health aspects
Hearing loss
Hearing Loss, Central - blood
Hearing Loss, Central - diagnosis
Hearing Loss, Central - epidemiology
Hearing Loss, Central - etiology
Hearing Loss, Sensorineural - blood
Hearing Loss, Sensorineural - diagnosis
Hearing Loss, Sensorineural - epidemiology
Hearing Loss, Sensorineural - etiology
Humans
Hyperbilirubinemia
Hyperbilirubinemia, Neonatal - blood
Hyperbilirubinemia, Neonatal - complications
Hyperbilirubinemia, Neonatal - diagnosis
Incidence
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - blood
Infant, Premature, Diseases - diagnosis
Infant, Premature, Diseases - epidemiology
Infant, Premature, Diseases - etiology
Infants
Infants (Premature)
Jaundice
Longitudinal Studies
Male
Neonates
Neuropathy
Pediatrics
Premature infants
Prospective Studies
Regression analysis
Risk Assessment
Risk Factors
ROC Curve
Serum Albumin - metabolism
Toxicity
Transfusion
title Chronic Auditory Toxicity in Late Preterm and Term Infants With Significant Hyperbilirubinemia
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T12%3A58%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20Auditory%20Toxicity%20in%20Late%20Preterm%20and%20Term%20Infants%20With%20Significant%20Hyperbilirubinemia&rft.jtitle=Pediatrics%20(Evanston)&rft.au=Amin,%20Sanjiv%20B&rft.date=2017-10&rft.volume=140&rft.issue=4&rft.spage=1&rft.pages=1-&rft.issn=0031-4005&rft.eissn=1098-4275&rft_id=info:doi/10.1542/peds.2016-4009&rft_dat=%3Cgale_pubme%3EA527591216%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1966084806&rft_id=info:pmid/28954873&rft_galeid=A527591216&rfr_iscdi=true