Genomic instability during reprogramming by nuclear transfer is DNA replication dependent

Somatic cells can be reprogrammed to a pluripotent state by nuclear transfer into oocytes, yet developmental arrest often occurs. While incomplete transcriptional reprogramming is known to cause developmental failure, reprogramming also involves concurrent changes in cell cycle progression and nucle...

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Veröffentlicht in:	Nature cell biology 2017-04, Vol.19 (4), p.282-291
Hauptverfasser:	Chia, Gloryn, Agudo, Judith, Treff, Nathan, Sauer, Mark V., Billing, David, Brown, Brian D., Baer, Richard, Egli, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 631/136/532/2435 631/337/1427 631/80/641/151 Animals BRCA1 protein BRCA1 Protein - metabolism Cancer Research Cell Biology Cell cycle Cell differentiation Cell Nucleus - metabolism Cellular Reprogramming - genetics Cellular structure Chromatin Chromosome Segregation - genetics Chromosomes, Human - metabolism Deoxyribonucleic acid Developmental Biology DNA DNA biosynthesis DNA damage DNA Damage - genetics DNA Repair - genetics DNA replication DNA Replication - genetics Embryo, Mammalian - metabolism Embryos Female Gene expression Genetic aspects Genetic research Genome, Human Genomes Genomic Instability Humans Interphase - genetics Life Sciences Mice Mice, Inbred C57BL - genetics Mitosis Mitosis - genetics Mouse Embryonic Stem Cells Nuclear structure Nuclear transfer Nuclear Transfer Techniques Oocytes Pluripotency Replication Somatic cells Stability Stem Cells Transcription Transcription, Genetic
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