Population Modeling Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Clinical Outcome in Patients With Sunitinib‐Treated Cancer

The tyrosine kinase inhibitor sunitinib is used as first‐line therapy in patients with metastasized renal cell carcinoma (mRCC), given in fixed‐dose regimens despite its high variability in pharmacokinetics (PKs). Interindividual variability of drug exposure may be responsible for differences in res...

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Veröffentlicht in:	CPT: pharmacometrics and systems pharmacology 2017-09, Vol.6 (9), p.604-613
Hauptverfasser:	Diekstra, MH, Fritsch, A, Kanefendt, F, Swen, JJ, Moes, DJAR, Sörgel, F, Kinzig, M, Stelzer, C, Schindele, D, Gauler, T, Hauser, S, Houtsma, D, Roessler, M, Moritz, B, Mross, K, Bergmann, L, Oosterwijk, E, Kiemeney, LA, Guchelaar, HJ, Jaehde, U
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents - blood Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use ATP Binding Cassette Transporter, Subfamily B - genetics Biomarkers Carcinoma, Renal Cell - blood Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - genetics Clinical outcomes Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Cytochrome P-450 CYP3A - genetics Drug dosages Female Genotype Humans Indoles - blood Indoles - pharmacokinetics Indoles - pharmacology Indoles - therapeutic use Interleukin-8 - genetics Kidney cancer Kidney Neoplasms - blood Kidney Neoplasms - drug therapy Kidney Neoplasms - genetics Male Middle Aged Models, Biological Original Patients Pharmacodynamics Pharmacokinetics Polymorphism, Single Nucleotide Protein Kinase Inhibitors - blood Protein Kinase Inhibitors - pharmacokinetics Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Pyrroles - blood Pyrroles - pharmacokinetics Pyrroles - pharmacology Pyrroles - therapeutic use Studies Sunitinib Targeted cancer therapy Treatment Outcome Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor Receptor-2 - blood Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-3 - blood Vascular Endothelial Growth Factor Receptor-3 - genetics
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