CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana

OBJECTIVES:To determine the association between cytochrome p450 2B6 genotypes and efavirenz-based HIV treatment outcomes. DESIGN:Observational cohort study of HIV-infected adults initiating efavirenz-based regimens in Botswana. METHODS:The primary endpoint was a composite of death or loss to care or...

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Veröffentlicht in:	AIDS (London) 2017-09, Vol.31 (15), p.2107-2113
Hauptverfasser:	Gross, Robert, Bellamy, Scarlett L, Ratshaa, Bakgaki, Han, Xiaoyan, Vujkovic, Marijana, Aplenc, Richard, Steenhoff, Andrew P, Mosepele, Mosepele, Moorthy, Ganesh, Zuppa, Athena F, Strom, Brian L, Bisson, Gregory P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Benzoxazines - adverse effects Benzoxazines - therapeutic use Botswana Cytochrome P-450 CYP2B6 - genetics Drug-Related Side Effects and Adverse Reactions - epidemiology Female Genotype Genotyping Techniques HIV Infections - drug therapy Humans Male Middle Aged Prospective Studies RNA, Viral - blood Surveys and Questionnaires Survival Analysis Treatment Outcome Viral Load Young Adult
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