Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors

Sonic hedgehog (SHH) is an essential morphogenetic signal that dictates cell fate decisions in several developing organs in mammals. data suggest that SHH is required to specify LHX3 /LHX4 Rathke's pouch (RP) progenitor identity. However, studies have failed to reveal such a function, supportin...

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Veröffentlicht in:	Development (Cambridge) 2017-09, Vol.144 (18), p.3289-3302
Hauptverfasser:	Carreno, Gabriela, Apps, John R, Lodge, Emily J, Panousopoulos, Leonidas, Haston, Scott, Gonzalez-Meljem, Jose Mario, Hahn, Heidi, Andoniadou, Cynthia L, Martinez-Barbera, Juan Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Compartmentation Cell Count Cell Differentiation Cell fate Cell Lineage Cell Proliferation Clonal deletion Clone Cells Crosses, Genetic Ectoderm - embryology Ectoderm - metabolism Embryo, Mammalian - metabolism Endoderm - embryology Endoderm - metabolism Epithelium Epithelium - embryology Epithelium - metabolism Female Gene Expression Regulation, Developmental Genotype Gestation Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humans Hyperplasia Hypothalamus (anterior) Hypothalamus - embryology Hypothalamus - metabolism LIM-Homeodomain Proteins - metabolism Male Mutation - genetics Pituitary Pituitary Gland - embryology Pituitary Gland - metabolism Pituitary Gland - pathology Signal Transduction Stem Cells Transcription Factors - metabolism
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