The Diabetic Dog as a Translational Model for Human Islet Transplantation
The dog model has served as the primary method for early development of many diabetes therapies, including pancreatic islet transplantation techniques and immunosuppressive protocols. Recent trends towards the use of monoclonal antibody therapies for immunosuppression in human islet transplantation...
Gespeichert in:
| Veröffentlicht in: | The Yale journal of biology & medicine 2017-09, Vol.90 (3), p.509-515 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 515 |
|---|---|
| container_issue | 3 |
| container_start_page | 509 |
| container_title | The Yale journal of biology & medicine |
| container_volume | 90 |
| creator | Adin, Christopher A Gilor, Chen |
| description | The dog model has served as the primary method for early development of many diabetes therapies, including pancreatic islet transplantation techniques and immunosuppressive protocols. Recent trends towards the use of monoclonal antibody therapies for immunosuppression in human islet transplantation have led to the increasing use of primate models with induced diabetes. In addition to induced-disease models in large animals, scientists in many fields are considering the use of naturally-occurring disease models in client-owned pets. This article will review the applicability of naturally-occurring diabetes in dogs as a translational model for developing islet transplantation in the human diabetic patient. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5612193</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1944441638</sourcerecordid><originalsourceid>FETCH-LOGICAL-p294t-84eaff3cdcb92259d05e6b45e09ef2040cc47b4b9529f687ee03e9e9b34bb3cd3</originalsourceid><addsrcrecordid>eNpdkF9LwzAUxYMobk6_ggR88aWQ5k_bvAiyqRtMfJnPIWlvt4y0qU0r-O0Nbop6X-7D_d3DOecETVMh0oQTkZ2iKSGcJ4QU2QRdhLAnhIlUsHM0oYWMWCGnaLXZAV5YbWCwJV74LdYBa7zpdRucHqxvtcPPvgKHa9_j5djoFq-Cg-HAdE63wxd3ic5q7QJcHfcMvT4-bObLZP3ytJrfr5OOSj4kBQdd16ysSiMpFbIiAjLDBRAJNSWclCXPDTdSUFlnRQ5AGEiQhnFj4hubobuDbjeaBqoS2qHXTnW9bXT_oby26u-ltTu19e9KZClNJYsCt0eB3r-NEAbV2FCCi0nAj0GlksdJM1ZE9OYfuvdjHysJiuZUUFbkLIvU9W9HP1a-W2afzPx6OQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2725238736</pqid></control><display><type>article</type><title>The Diabetic Dog as a Translational Model for Human Islet Transplantation</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Adin, Christopher A ; Gilor, Chen</creator><creatorcontrib>Adin, Christopher A ; Gilor, Chen</creatorcontrib><description>The dog model has served as the primary method for early development of many diabetes therapies, including pancreatic islet transplantation techniques and immunosuppressive protocols. Recent trends towards the use of monoclonal antibody therapies for immunosuppression in human islet transplantation have led to the increasing use of primate models with induced diabetes. In addition to induced-disease models in large animals, scientists in many fields are considering the use of naturally-occurring disease models in client-owned pets. This article will review the applicability of naturally-occurring diabetes in dogs as a translational model for developing islet transplantation in the human diabetic patient.</description><identifier>ISSN: 0044-0086</identifier><identifier>EISSN: 1551-4056</identifier><identifier>PMID: 28955189</identifier><language>eng</language><publisher>United States: Yale Journal of Biology and Medicine</publisher><subject>Animal models ; Animals ; Antibodies, Monoclonal - immunology ; Antigens ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - immunology ; Diabetes Mellitus - surgery ; Disease ; Dogs ; Drugs ; Glucose monitoring ; Haplotypes ; Histology ; Humans ; Hyperglycemia ; Immunosuppression ; Immunosuppressive agents ; Immunotherapy ; Insulin ; Islet cells ; Islets of Langerhans Transplantation ; Monoclonal antibodies ; Pancreas transplantation ; Pancreatic islet transplantation ; Pets ; Pharmacokinetics ; Translation ; Transplants & implants</subject><ispartof>The Yale journal of biology & medicine, 2017-09, Vol.90 (3), p.509-515</ispartof><rights>2017. This work is published under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Sourced from the United States National Library of Medicine® (NLM). This work may not reflect the most current or accurate data available from NLM.</rights><rights>Copyright ©2017, Yale Journal of Biology and Medicine 2017 Yale Journal of Biology and Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612193/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612193/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28955189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adin, Christopher A</creatorcontrib><creatorcontrib>Gilor, Chen</creatorcontrib><title>The Diabetic Dog as a Translational Model for Human Islet Transplantation</title><title>The Yale journal of biology & medicine</title><addtitle>Yale J Biol Med</addtitle><description>The dog model has served as the primary method for early development of many diabetes therapies, including pancreatic islet transplantation techniques and immunosuppressive protocols. Recent trends towards the use of monoclonal antibody therapies for immunosuppression in human islet transplantation have led to the increasing use of primate models with induced diabetes. In addition to induced-disease models in large animals, scientists in many fields are considering the use of naturally-occurring disease models in client-owned pets. This article will review the applicability of naturally-occurring diabetes in dogs as a translational model for developing islet transplantation in the human diabetic patient.</description><subject>Animal models</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - immunology</subject><subject>Diabetes Mellitus - surgery</subject><subject>Disease</subject><subject>Dogs</subject><subject>Drugs</subject><subject>Glucose monitoring</subject><subject>Haplotypes</subject><subject>Histology</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Immunosuppression</subject><subject>Immunosuppressive agents</subject><subject>Immunotherapy</subject><subject>Insulin</subject><subject>Islet cells</subject><subject>Islets of Langerhans Transplantation</subject><subject>Monoclonal antibodies</subject><subject>Pancreas transplantation</subject><subject>Pancreatic islet transplantation</subject><subject>Pets</subject><subject>Pharmacokinetics</subject><subject>Translation</subject><subject>Transplants & implants</subject><issn>0044-0086</issn><issn>1551-4056</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkF9LwzAUxYMobk6_ggR88aWQ5k_bvAiyqRtMfJnPIWlvt4y0qU0r-O0Nbop6X-7D_d3DOecETVMh0oQTkZ2iKSGcJ4QU2QRdhLAnhIlUsHM0oYWMWCGnaLXZAV5YbWCwJV74LdYBa7zpdRucHqxvtcPPvgKHa9_j5djoFq-Cg-HAdE63wxd3ic5q7QJcHfcMvT4-bObLZP3ytJrfr5OOSj4kBQdd16ysSiMpFbIiAjLDBRAJNSWclCXPDTdSUFlnRQ5AGEiQhnFj4hubobuDbjeaBqoS2qHXTnW9bXT_oby26u-ltTu19e9KZClNJYsCt0eB3r-NEAbV2FCCi0nAj0GlksdJM1ZE9OYfuvdjHysJiuZUUFbkLIvU9W9HP1a-W2afzPx6OQ</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Adin, Christopher A</creator><creator>Gilor, Chen</creator><general>Yale Journal of Biology and Medicine</general><general>YJBM</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170901</creationdate><title>The Diabetic Dog as a Translational Model for Human Islet Transplantation</title><author>Adin, Christopher A ; Gilor, Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p294t-84eaff3cdcb92259d05e6b45e09ef2040cc47b4b9529f687ee03e9e9b34bb3cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - immunology</topic><topic>Diabetes Mellitus - surgery</topic><topic>Disease</topic><topic>Dogs</topic><topic>Drugs</topic><topic>Glucose monitoring</topic><topic>Haplotypes</topic><topic>Histology</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Immunosuppression</topic><topic>Immunosuppressive agents</topic><topic>Immunotherapy</topic><topic>Insulin</topic><topic>Islet cells</topic><topic>Islets of Langerhans Transplantation</topic><topic>Monoclonal antibodies</topic><topic>Pancreas transplantation</topic><topic>Pancreatic islet transplantation</topic><topic>Pets</topic><topic>Pharmacokinetics</topic><topic>Translation</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adin, Christopher A</creatorcontrib><creatorcontrib>Gilor, Chen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Yale journal of biology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adin, Christopher A</au><au>Gilor, Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Diabetic Dog as a Translational Model for Human Islet Transplantation</atitle><jtitle>The Yale journal of biology & medicine</jtitle><addtitle>Yale J Biol Med</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>90</volume><issue>3</issue><spage>509</spage><epage>515</epage><pages>509-515</pages><issn>0044-0086</issn><eissn>1551-4056</eissn><abstract>The dog model has served as the primary method for early development of many diabetes therapies, including pancreatic islet transplantation techniques and immunosuppressive protocols. Recent trends towards the use of monoclonal antibody therapies for immunosuppression in human islet transplantation have led to the increasing use of primate models with induced diabetes. In addition to induced-disease models in large animals, scientists in many fields are considering the use of naturally-occurring disease models in client-owned pets. This article will review the applicability of naturally-occurring diabetes in dogs as a translational model for developing islet transplantation in the human diabetic patient.</abstract><cop>United States</cop><pub>Yale Journal of Biology and Medicine</pub><pmid>28955189</pmid><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0044-0086 |
| ispartof | The Yale journal of biology & medicine, 2017-09, Vol.90 (3), p.509-515 |
| issn | 0044-0086 1551-4056 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5612193 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animal models Animals Antibodies, Monoclonal - immunology Antigens Diabetes Diabetes mellitus Diabetes Mellitus - immunology Diabetes Mellitus - surgery Disease Dogs Drugs Glucose monitoring Haplotypes Histology Humans Hyperglycemia Immunosuppression Immunosuppressive agents Immunotherapy Insulin Islet cells Islets of Langerhans Transplantation Monoclonal antibodies Pancreas transplantation Pancreatic islet transplantation Pets Pharmacokinetics Translation Transplants & implants |
| title | The Diabetic Dog as a Translational Model for Human Islet Transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T02%3A52%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Diabetic%20Dog%20as%20a%20Translational%20Model%20for%20Human%20Islet%20Transplantation&rft.jtitle=The%20Yale%20journal%20of%20biology%20&%20medicine&rft.au=Adin,%20Christopher%20A&rft.date=2017-09-01&rft.volume=90&rft.issue=3&rft.spage=509&rft.epage=515&rft.pages=509-515&rft.issn=0044-0086&rft.eissn=1551-4056&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1944441638%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2725238736&rft_id=info:pmid/28955189&rfr_iscdi=true |