Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans

Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia c...

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Veröffentlicht in:The Journal of biological chemistry 2017-09, Vol.292 (38), p.15588-15597
Hauptverfasser: Hu, Jinchuan, Selby, Christopher P., Adar, Sheera, Adebali, Ogun, Sancar, Aziz
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container_issue 38
container_start_page 15588
container_title The Journal of biological chemistry
container_volume 292
creator Hu, Jinchuan
Selby, Christopher P.
Adar, Sheera
Adebali, Ogun
Sancar, Aziz
description Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection
subjects carcinogenesis
chemotherapy
Chromosome Mapping - methods
damage mapping
damage recognition
DNA Damage
DNA Repair - genetics
Escherichia coli - genetics
Humans
kinetic proofreading
Minireviews
repair mapping
title Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans
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