Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans
Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia c...
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Veröffentlicht in: | The Journal of biological chemistry 2017-09, Vol.292 (38), p.15588-15597 |
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creator | Hu, Jinchuan Selby, Christopher P. Adar, Sheera Adebali, Ogun Sancar, Aziz |
description | Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution. |
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In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. 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In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28798238</pmid><doi>10.1074/jbc.R117.807453</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | carcinogenesis chemotherapy Chromosome Mapping - methods damage mapping damage recognition DNA Damage DNA Repair - genetics Escherichia coli - genetics Humans kinetic proofreading Minireviews repair mapping |
title | Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans |
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