Trichostatin A Sensitizes Hepatocellular Carcinoma Cells to Enhanced NK Cell-mediated Killing by Regulating Immune-related Genes

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The ability of HCC to avoid immune detection is considered one of the main factors making it difficult to cure. Abnormal histone deacetylation is thought to be one of the mechanisms for HCC immune escape, m...

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Veröffentlicht in:	Cancer Genomics & Proteomics 2017-09, Vol.14 (5), p.349-362
Hauptverfasser:	Shin, Sangsu, Kim, Miok, Lee, Seon-Jin, Park, Kang-Seo, Lee, Chang Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - pathology Female Gene Expression Regulation, Neoplastic - drug effects Hep G2 Cells Humans Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Hydroxamic Acids - therapeutic use Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Ligands Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - immunology Liver Neoplasms - pathology Mice, Inbred BALB C Mice, Nude NK Cell Lectin-Like Receptor Subfamily K - metabolism Xenograft Model Antitumor Assays
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