p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes

The maintenance of a proper nuclear architecture and three-dimensional organization of the genes, enhancer elements, and transcription machinery plays an essential role in tissue development and regeneration. Here we show that in the developing skin, epidermal progenitor cells of mice lacking p63 tr...

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Veröffentlicht in:	Journal of investigative dermatology 2017-10, Vol.137 (10), p.2157-2167
Hauptverfasser:	Rapisarda, Valentina, Malashchuk, Igor, Asamaowei, Inemo E., Poterlowicz, Krzysztof, Fessing, Michael Y., Sharov, Andrey A., Karakesisoglou, Iakowos, Botchkarev, Vladimir A., Mardaryev, Andrei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Nucleus - metabolism Epidermis - metabolism Epidermis - pathology Gene Expression Regulation, Developmental Humans Keratinocytes - metabolism Keratinocytes - pathology Mice Models, Animal Nuclear Envelope - genetics Nuclear Envelope - metabolism Original Phosphoproteins - biosynthesis Phosphoproteins - genetics RNA - genetics Trans-Activators - biosynthesis Trans-Activators - genetics Transcription Factors - genetics Transcription, Genetic
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