Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice
The cognitive effect of Artemisia argyi H. under liquid-state fermentation by Monascus purpureus (AAFM), which has cellular antioxidant activity and neuronal cell viability, on trimethyltin- (TMT-) induced learning and memory impairment in Institute of Cancer Research (ICR) mice was confirmed. Tests...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-16 |
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| creator | Heo, Ho Jin Ha, Gi Jeong Kim, Jong Min Ha, Jeong Su Park, Seon Kyeong Lee, Du Sang Kang, Jin Yong Seo, Weon Taek |
| description | The cognitive effect of Artemisia argyi H. under liquid-state fermentation by Monascus purpureus (AAFM), which has cellular antioxidant activity and neuronal cell viability, on trimethyltin- (TMT-) induced learning and memory impairment in Institute of Cancer Research (ICR) mice was confirmed. Tests were conducted to determine the neuroprotective effects against H2O2-induced oxidative stress, and the results showed that AAFM has protective effects through the repression of mitochondrial injury and cellular membrane damage against H2O2-induced neurotoxicity. In animal experiments, such as the Y-maze, passive avoidance, and Morris water maze tests, AAFM also showed excellent ameliorating effects on TMT-induced cognitive dysfunction. After behavioral tests, brain tissues were extracted to assess damage to brain tissue. According to the experimental results, AAFM improved the cholinergic system by upregulating acetylcholine (ACh) contents and inhibiting acetylcholinesterase (AChE) activity. AAFM effectively improved the decline of the superoxide dismutase (SOD) level and the increase of the oxidized glutathione (GSH) ratio and lipid peroxidation (malondialdehyde (MDA) production) caused by TMT-induced oxidative stress. The occurrence of mitochondrial dysfunction and apoptosis was also decreased compared with the TMT group. Finally, quinic acid derivatives were identified as the major phenolic compounds in AAFM using ultra-performance liquid chromatography quadrupole-time-of-flight (UPLC-Q-TOF) MS analysis. |
| doi_str_mv | 10.1155/2017/5809370 |
| format | Article |
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Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice</title><source>PubMed (Medline)</source><source>Wiley Online Library Open Access</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Heo, Ho Jin ; Ha, Gi Jeong ; Kim, Jong Min ; Ha, Jeong Su ; Park, Seon Kyeong ; Lee, Du Sang ; Kang, Jin Yong ; Seo, Weon Taek</creator><contributor>Kim, Youn C.</contributor><creatorcontrib>Heo, Ho Jin ; Ha, Gi Jeong ; Kim, Jong Min ; Ha, Jeong Su ; Park, Seon Kyeong ; Lee, Du Sang ; Kang, Jin Yong ; Seo, Weon Taek ; Kim, Youn C.</creatorcontrib><description>The cognitive effect of Artemisia argyi H. under liquid-state fermentation by Monascus purpureus (AAFM), which has cellular antioxidant activity and neuronal cell viability, on trimethyltin- (TMT-) induced learning and memory impairment in Institute of Cancer Research (ICR) mice was confirmed. Tests were conducted to determine the neuroprotective effects against H2O2-induced oxidative stress, and the results showed that AAFM has protective effects through the repression of mitochondrial injury and cellular membrane damage against H2O2-induced neurotoxicity. In animal experiments, such as the Y-maze, passive avoidance, and Morris water maze tests, AAFM also showed excellent ameliorating effects on TMT-induced cognitive dysfunction. After behavioral tests, brain tissues were extracted to assess damage to brain tissue. According to the experimental results, AAFM improved the cholinergic system by upregulating acetylcholine (ACh) contents and inhibiting acetylcholinesterase (AChE) activity. AAFM effectively improved the decline of the superoxide dismutase (SOD) level and the increase of the oxidized glutathione (GSH) ratio and lipid peroxidation (malondialdehyde (MDA) production) caused by TMT-induced oxidative stress. The occurrence of mitochondrial dysfunction and apoptosis was also decreased compared with the TMT group. Finally, quinic acid derivatives were identified as the major phenolic compounds in AAFM using ultra-performance liquid chromatography quadrupole-time-of-flight (UPLC-Q-TOF) MS analysis.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2017/5809370</identifier><identifier>PMID: 29081819</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acetylcholinesterase ; Alzheimer's disease ; Animal research ; Animal tissues ; Antioxidants ; Apoptosis ; Biochemistry ; Brain ; Brain injury ; Cancer ; Cholinergic transmission ; Cognitive ability ; Cytochrome ; Fermentation ; Fungi ; Genetic aspects ; Glutathione ; Hydrogen peroxide ; Learning ; Life sciences ; Lipid peroxidation ; Liquid chromatography ; Malondialdehyde ; Memory ; Microorganisms ; Mitochondria ; Monascus purpureus ; Mugwort ; Nervous system ; Neuroprotection ; Neurotoxicity ; Oxidative stress ; Peroxidation ; Phenolic compounds ; Phenols ; Quadrupoles ; Quinic acid ; Rats ; Rattus ; Rice ; Signal transduction ; Superoxide dismutase ; Trimethyltin</subject><ispartof>Evidence-based complementary and alternative medicine, 2017-01, Vol.2017 (2017), p.1-16</ispartof><rights>Copyright © 2017 Jin Yong Kang et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Jin Yong Kang et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Jin Yong Kang et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-c514d8b8fd9c143c313dd4b961f5f39f070837f6c7beda004d5d9a602afd0fab3</citedby><cites>FETCH-LOGICAL-c499t-c514d8b8fd9c143c313dd4b961f5f39f070837f6c7beda004d5d9a602afd0fab3</cites><orcidid>0000-0002-3560-2007</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610803/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610803/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29081819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kim, Youn C.</contributor><creatorcontrib>Heo, Ho Jin</creatorcontrib><creatorcontrib>Ha, Gi Jeong</creatorcontrib><creatorcontrib>Kim, Jong Min</creatorcontrib><creatorcontrib>Ha, Jeong Su</creatorcontrib><creatorcontrib>Park, Seon Kyeong</creatorcontrib><creatorcontrib>Lee, Du Sang</creatorcontrib><creatorcontrib>Kang, Jin Yong</creatorcontrib><creatorcontrib>Seo, Weon Taek</creatorcontrib><title>Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>The cognitive effect of Artemisia argyi H. under liquid-state fermentation by Monascus purpureus (AAFM), which has cellular antioxidant activity and neuronal cell viability, on trimethyltin- (TMT-) induced learning and memory impairment in Institute of Cancer Research (ICR) mice was confirmed. Tests were conducted to determine the neuroprotective effects against H2O2-induced oxidative stress, and the results showed that AAFM has protective effects through the repression of mitochondrial injury and cellular membrane damage against H2O2-induced neurotoxicity. In animal experiments, such as the Y-maze, passive avoidance, and Morris water maze tests, AAFM also showed excellent ameliorating effects on TMT-induced cognitive dysfunction. After behavioral tests, brain tissues were extracted to assess damage to brain tissue. According to the experimental results, AAFM improved the cholinergic system by upregulating acetylcholine (ACh) contents and inhibiting acetylcholinesterase (AChE) activity. AAFM effectively improved the decline of the superoxide dismutase (SOD) level and the increase of the oxidized glutathione (GSH) ratio and lipid peroxidation (malondialdehyde (MDA) production) caused by TMT-induced oxidative stress. The occurrence of mitochondrial dysfunction and apoptosis was also decreased compared with the TMT group. Finally, quinic acid derivatives were identified as the major phenolic compounds in AAFM using ultra-performance liquid chromatography quadrupole-time-of-flight (UPLC-Q-TOF) MS analysis.</description><subject>Acetylcholinesterase</subject><subject>Alzheimer's disease</subject><subject>Animal research</subject><subject>Animal tissues</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Brain</subject><subject>Brain injury</subject><subject>Cancer</subject><subject>Cholinergic transmission</subject><subject>Cognitive ability</subject><subject>Cytochrome</subject><subject>Fermentation</subject><subject>Fungi</subject><subject>Genetic aspects</subject><subject>Glutathione</subject><subject>Hydrogen peroxide</subject><subject>Learning</subject><subject>Life sciences</subject><subject>Lipid peroxidation</subject><subject>Liquid chromatography</subject><subject>Malondialdehyde</subject><subject>Memory</subject><subject>Microorganisms</subject><subject>Mitochondria</subject><subject>Monascus purpureus</subject><subject>Mugwort</subject><subject>Nervous system</subject><subject>Neuroprotection</subject><subject>Neurotoxicity</subject><subject>Oxidative stress</subject><subject>Peroxidation</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>Quadrupoles</subject><subject>Quinic acid</subject><subject>Rats</subject><subject>Rattus</subject><subject>Rice</subject><subject>Signal transduction</subject><subject>Superoxide dismutase</subject><subject>Trimethyltin</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNksGLEzEYxQdR3LV68ywBL4J2N5lJJpOLUKp1Cy2CVPAWMsmXbpaZpCYzKz37j5vS2lVPQiAf5MdLXt4ripcEXxHC2HWJCb9mDRYVx4-KS8IpmdKyaR6fZ_7toniW0h3GpeCcPy0uSoEb0hBxWfych613g7sHtBi9HlzwKFg0iwP0LjmFVNzuHbq5QguIPfgBDGr3aB28SnpMaDfGvCBPozcQ0Wa9mS69GXXmVqCid36LlDdoDX2Ie_QBrNNuSMh5tJx_QWun4XnxxKouwYvTPim-Lj5u5jfT1edPy_lsNdVUiGGqGaGmaRtrhCa00hWpjKGtqIllthIWc9xU3Naat2AUxtQwI1SNS2UNtqqtJsX7o-5ubHswOruJqpO76HoV9zIoJ_8-8e5WbsO9ZDXBDa6ywJuTQAzfR0iDzH-koeuUhzAmSQTjvOY0ZzEpXv-D3oUx-mwvU7QkOaGaPlBb1YF03oZ8rz6IyhljNa4pxTxT746UjiGlCPb8ZILloQPy0AF56kDGX_1p8wz_Dj0Db4_ArfNG_XD_KQeZAaseaMIoIU31CxLQw0s</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Heo, Ho Jin</creator><creator>Ha, Gi Jeong</creator><creator>Kim, Jong Min</creator><creator>Ha, Jeong Su</creator><creator>Park, Seon Kyeong</creator><creator>Lee, Du Sang</creator><creator>Kang, Jin Yong</creator><creator>Seo, Weon Taek</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3560-2007</orcidid></search><sort><creationdate>20170101</creationdate><title>Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice</title><author>Heo, Ho Jin ; Ha, Gi Jeong ; Kim, Jong Min ; Ha, Jeong Su ; Park, Seon Kyeong ; Lee, Du Sang ; Kang, Jin Yong ; Seo, Weon Taek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-c514d8b8fd9c143c313dd4b961f5f39f070837f6c7beda004d5d9a602afd0fab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetylcholinesterase</topic><topic>Alzheimer's disease</topic><topic>Animal research</topic><topic>Animal tissues</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Brain</topic><topic>Brain injury</topic><topic>Cancer</topic><topic>Cholinergic transmission</topic><topic>Cognitive ability</topic><topic>Cytochrome</topic><topic>Fermentation</topic><topic>Fungi</topic><topic>Genetic aspects</topic><topic>Glutathione</topic><topic>Hydrogen peroxide</topic><topic>Learning</topic><topic>Life sciences</topic><topic>Lipid peroxidation</topic><topic>Liquid chromatography</topic><topic>Malondialdehyde</topic><topic>Memory</topic><topic>Microorganisms</topic><topic>Mitochondria</topic><topic>Monascus purpureus</topic><topic>Mugwort</topic><topic>Nervous system</topic><topic>Neuroprotection</topic><topic>Neurotoxicity</topic><topic>Oxidative stress</topic><topic>Peroxidation</topic><topic>Phenolic compounds</topic><topic>Phenols</topic><topic>Quadrupoles</topic><topic>Quinic acid</topic><topic>Rats</topic><topic>Rattus</topic><topic>Rice</topic><topic>Signal transduction</topic><topic>Superoxide dismutase</topic><topic>Trimethyltin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heo, Ho Jin</creatorcontrib><creatorcontrib>Ha, Gi Jeong</creatorcontrib><creatorcontrib>Kim, Jong Min</creatorcontrib><creatorcontrib>Ha, Jeong Su</creatorcontrib><creatorcontrib>Park, Seon Kyeong</creatorcontrib><creatorcontrib>Lee, Du Sang</creatorcontrib><creatorcontrib>Kang, Jin Yong</creatorcontrib><creatorcontrib>Seo, Weon Taek</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heo, Ho Jin</au><au>Ha, Gi Jeong</au><au>Kim, Jong Min</au><au>Ha, Jeong Su</au><au>Park, Seon Kyeong</au><au>Lee, Du Sang</au><au>Kang, Jin Yong</au><au>Seo, Weon Taek</au><au>Kim, Youn C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>16</epage><pages>1-16</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>The cognitive effect of Artemisia argyi H. under liquid-state fermentation by Monascus purpureus (AAFM), which has cellular antioxidant activity and neuronal cell viability, on trimethyltin- (TMT-) induced learning and memory impairment in Institute of Cancer Research (ICR) mice was confirmed. Tests were conducted to determine the neuroprotective effects against H2O2-induced oxidative stress, and the results showed that AAFM has protective effects through the repression of mitochondrial injury and cellular membrane damage against H2O2-induced neurotoxicity. In animal experiments, such as the Y-maze, passive avoidance, and Morris water maze tests, AAFM also showed excellent ameliorating effects on TMT-induced cognitive dysfunction. After behavioral tests, brain tissues were extracted to assess damage to brain tissue. According to the experimental results, AAFM improved the cholinergic system by upregulating acetylcholine (ACh) contents and inhibiting acetylcholinesterase (AChE) activity. AAFM effectively improved the decline of the superoxide dismutase (SOD) level and the increase of the oxidized glutathione (GSH) ratio and lipid peroxidation (malondialdehyde (MDA) production) caused by TMT-induced oxidative stress. The occurrence of mitochondrial dysfunction and apoptosis was also decreased compared with the TMT group. Finally, quinic acid derivatives were identified as the major phenolic compounds in AAFM using ultra-performance liquid chromatography quadrupole-time-of-flight (UPLC-Q-TOF) MS analysis.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29081819</pmid><doi>10.1155/2017/5809370</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-3560-2007</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylcholinesterase Alzheimer's disease Animal research Animal tissues Antioxidants Apoptosis Biochemistry Brain Brain injury Cancer Cholinergic transmission Cognitive ability Cytochrome Fermentation Fungi Genetic aspects Glutathione Hydrogen peroxide Learning Life sciences Lipid peroxidation Liquid chromatography Malondialdehyde Memory Microorganisms Mitochondria Monascus purpureus Mugwort Nervous system Neuroprotection Neurotoxicity Oxidative stress Peroxidation Phenolic compounds Phenols Quadrupoles Quinic acid Rats Rattus Rice Signal transduction Superoxide dismutase Trimethyltin |
| title | Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice |
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